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Comparison of Functional β-cell Function and Insulin Sensitivity of Functioning Pancreas Transplant According to Pre-Transplant Matsuda’s Index

S. Shin, Y. Ko, D. Kim, J. Kim, H. Kwon, J. Choi, J. Jung, Y. Kim, D. Han

Division of Kidney and Pancreas Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of

Meeting: 2019 American Transplant Congress

Abstract number: D289

Keywords: Insulin, Pancreas transplantation

Session Information

Date: Tuesday, June 4, 2019

Session Name: Poster Session D: Pancreas and Islet: All Topics

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall C & D

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*Purpose: This study was performed to verify post-transplant improvement of functioning β-cell mass and insulin sensitivity of functioning pancreas transplants according to the degree of pre-transplant insulin sensitivity.

*Methods: To compare the metabolic effects of pancreas transplantation in terms of β-cell function and insulin sensitivity, comparison of metabolic variables was performed according to pre-transplant Matsuda’s index (MI) pre-transplant, one month and one year post-transplant.

*Results: Among 118 recipients who underwent pancreas transplantation at our center between April, 2015 and July, 2018, a total of 50 patients (MI≥5, n=25; MI<5, n=25) were performed oral glucose tolerance test pre-transplant and post-transplant one month and one year.Compared with pre-transplant, insulinogenic index significantly increased post-transplant one month and one year in recipients with pre-transplant MI≥5 (0.02±0.04 vs 0.31±1.32 vs 1.67±1.43, p=0.003) as well as in those with pre-transplant MI<5 (0.03±0.06 vs 1.18±1.90 vs 0.83±0.57, p<0.001). Compared with pre-transplant, Matsuda’s index post-transplant one month and one year significantly decreased in those with pre-transplant MI≥5 (10.14±5.17 vs 4.46±2.91 vs 3.43±0.99, p=0.001) whereas there was no significant difference in those with pre-transplant MI<5 (2.76±1.37 vs 3.39±1.97 vs 3.00±1.15, p=0.566). Compared with pre-transplant, on the other hand, the level of serum glucagon significantly decreased post-transplant one month and one year regardless of the degree of pre-transplant MI (602.7±538.9 vs 245.9±124.7 vs 251.5±164.2, p=0.009).

*Conclusions: We could not verify the improvement of insulin sensitivity post-transplant one month and one year according to the severity of pre-transplant insulin resistance. However, the decreased level of serum glucagon post-transplant might indicate the improvement of glucose control. Long-term follow up analysis is necessary to evaluate the beneficial effect of pancreas transplantation in terms of insulin sensitivity.

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To cite this abstract in AMA style:

Shin S, Ko Y, Kim D, Kim J, Kwon H, Choi J, Jung J, Kim Y, Han D. Comparison of Functional β-cell Function and Insulin Sensitivity of Functioning Pancreas Transplant According to Pre-Transplant Matsuda’s Index [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/comparison-of-functional-%ce%b2-cell-function-and-insulin-sensitivity-of-functioning-pancreas-transplant-according-to-pre-transplant-matsudas-index/. Accessed March 8, 2021.

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