Comparison of Functional β-cell Function and Insulin Sensitivity of Functioning Pancreas Transplant According to Pre-Transplant Matsuda’s Index
Division of Kidney and Pancreas Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of
Meeting: 2019 American Transplant Congress
Abstract number: D289
Keywords: Insulin, Pancreas transplantation
Session Information
Date: Tuesday, June 4, 2019
Session Name: Poster Session D: Pancreas and Islet: All Topics
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall C & D
*Purpose: This study was performed to verify post-transplant improvement of functioning β-cell mass and insulin sensitivity of functioning pancreas transplants according to the degree of pre-transplant insulin sensitivity.
*Methods: To compare the metabolic effects of pancreas transplantation in terms of β-cell function and insulin sensitivity, comparison of metabolic variables was performed according to pre-transplant Matsuda’s index (MI) pre-transplant, one month and one year post-transplant.
*Results: Among 118 recipients who underwent pancreas transplantation at our center between April, 2015 and July, 2018, a total of 50 patients (MI≥5, n=25; MI<5, n=25) were performed oral glucose tolerance test pre-transplant and post-transplant one month and one year.Compared with pre-transplant, insulinogenic index significantly increased post-transplant one month and one year in recipients with pre-transplant MI≥5 (0.02±0.04 vs 0.31±1.32 vs 1.67±1.43, p=0.003) as well as in those with pre-transplant MI<5 (0.03±0.06 vs 1.18±1.90 vs 0.83±0.57, p<0.001). Compared with pre-transplant, Matsuda’s index post-transplant one month and one year significantly decreased in those with pre-transplant MI≥5 (10.14±5.17 vs 4.46±2.91 vs 3.43±0.99, p=0.001) whereas there was no significant difference in those with pre-transplant MI<5 (2.76±1.37 vs 3.39±1.97 vs 3.00±1.15, p=0.566). Compared with pre-transplant, on the other hand, the level of serum glucagon significantly decreased post-transplant one month and one year regardless of the degree of pre-transplant MI (602.7±538.9 vs 245.9±124.7 vs 251.5±164.2, p=0.009).
*Conclusions: We could not verify the improvement of insulin sensitivity post-transplant one month and one year according to the severity of pre-transplant insulin resistance. However, the decreased level of serum glucagon post-transplant might indicate the improvement of glucose control. Long-term follow up analysis is necessary to evaluate the beneficial effect of pancreas transplantation in terms of insulin sensitivity.
To cite this abstract in AMA style:
Shin S, Ko Y, Kim D, Kim J, Kwon H, Choi J, Jung J, Kim Y, Han D. Comparison of Functional β-cell Function and Insulin Sensitivity of Functioning Pancreas Transplant According to Pre-Transplant Matsuda’s Index [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/comparison-of-functional-%ce%b2-cell-function-and-insulin-sensitivity-of-functioning-pancreas-transplant-according-to-pre-transplant-matsudas-index/. Accessed February 29, 2020.« Back to 2019 American Transplant Congress