Comparison of Creatinine Based Estimated Glomerular Filtration Rate (eGFR) and Iothalamate-Measured GFR (mGFR) Following Simultaneous Pancreas – Kidney Transplantation
University Hospitals Case Medical Center, Cleveland.
Meeting: 2015 American Transplant Congress
Abstract number: C210
Keywords: Renal function
Session Information
Session Name: Poster Session C: More Controversies in Pancreas Transplantation
Session Type: Poster Session
Date: Monday, May 4, 2015
Session Time: 5:30pm-6:30pm
Presentation Time: 5:30pm-6:30pm
Location: Exhibit Hall E
Objective: Creatinine based eGFR equations may overestimate the true GFR in simulataneous pancreas-kidney (SPK) transplant patients, owing to the low lean body mass in these patients. Inulin or iothalamate clearance is considered to be gold standard method of measuring true GFR. We sought to compare creatinine based eGFR and mGFR by iothalamate in this special population.
Methods: Iothalamate clearances were measured using single bolus injection, and following plasma clearance in five SPK patients at different intervals after transplant. These results were compared to eGFR values obtained using three different commonly used equations, namely, Modified Diet in Renal Disease (MDRD), Cockroft-Gault (CG), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI). T testing was utilized for comparing GFR measurements.
Results: There were 12 mGFR values done in 5 SPK recipients (4 males and 1 female) with baseline characteristics as shown in table 1.
| Age | BMI | Creatinine | mGFR | MDRD | CG | CKD-EPI | |
| Mean (SD) | 42(5) | 31(7) | 1.1(0.3) | 65(13) | 83(27) | 117(14) | 87(24) |
| Median | 42 | 30 | 1.0 | 65 | 83.5 | 117 | 89.5 |
| Range | 13 | 20 | 1.0 | 49 | 75 | 44 | 59 |
The differences between eGFR estimated by each of the three equations and the mGFR (table 2). While all of the results were significantly different from the mGFR, the MDRD-based eGFR values were the closest estimate.
| Comparison | Mean difference (95% CI) | P-Value |
| mGFR, and MDRD | -18 (-36, -1) | 0.04 |
| mGFR and CG | -52 (-60, -42) | <0.01 |
| mGFR and CKD-EPI | -22 (-37, -7) | <0.01 |
Conclusion: All the creatinine-based eGFR equations overestimated the true GFR as measured by iothalamate clearance. However, MDRD equation was the nearest estimate.
To cite this abstract in AMA style:
Sarabu N, Augustine J, Woodside K, Hricik D, Padiyar A, Sanchez E. Comparison of Creatinine Based Estimated Glomerular Filtration Rate (eGFR) and Iothalamate-Measured GFR (mGFR) Following Simultaneous Pancreas – Kidney Transplantation [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/comparison-of-creatinine-based-estimated-glomerular-filtration-rate-egfr-and-iothalamate-measured-gfr-mgfr-following-simultaneous-pancreas-kidney-transplantation/. Accessed November 21, 2024.« Back to 2015 American Transplant Congress