ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Comparable Outcomes for Simultaneous Liver-Kidney Transplantation with HCV NAT-Positive Donors

M. L. Samoylova1, B. I. Shaw1, S. J. Kesseli1, L. McElroy1, Y. Patel2, S. Sanoff2, A. S. Barbas1

1Surgery, Duke University Hospital, Durham, NC, 2Medicine, Duke University Hospital, Durham, NC

Meeting: 2020 American Transplant Congress

Abstract number: D-011

Keywords: Allocation, Hepatitis C, Kidney, Outcome

Session Information

Session Name: Poster Session D: Kidney Living Donor: Other

Session Type: Poster Session

Date: Saturday, May 30, 2020

Session Time: 3:15pm-4:00pm

 Presentation Time: 3:30pm-4:00pm

Location: Virtual

*Purpose: To evaluate the impact of hepatitis C virus (HCV) Nucleic Acid Amplification-positive (NAT+) donors on outcomes following simultaneous liver-kidney (SLK) transplantation.

*Methods: We used the UNOS database to identify the cohort of adult patients receiving SLK 2015 (NAT testing was mandated) to 2018. Patients listed before and after the July 10, 2017 change in SLK listing policy were analyzed separately. Patient and death-censored graft survival were compared at 1 year using chi-squared and multivariable Cox proportional hazard models adjusted for recipient gender, race, KDRI, and transplant MELD.

*Results: During this period, 2701 SLKs were performed in the US, 1790 before the SLK listing policy change and 911 after. In total, 227 (8.4%) patients received NAT+ donors, and 32 (14.5%) NAT+ grafts were used in HCV seronegative recipients (Figure 1). Compared to NAT- donors, NAT+ donors were of similar age, had higher KDPI (49% vs 34%, p<0.0005), and lower BMI (25 vs 26, p=0.001). Pre-policy, unadjusted 1-year patient survival trended higher in those receiving NAT+ than NAT-negative organs (94.5% vs 90.15%, p=0.088); 1-year liver graft survival was higher in NAT+ recipients (95.2% vs 89.8%, p=0.036). Post-policy, unadjusted 1-year survival was not affected by donor NAT status (NAT+90.2%, negative 91.3%, p=0.74), nor was graft survival (Figure 2). Post-policy risk-adjusted death did not differ by donor NAT status [HR 1.24 (95% CI 0.60-2.58, p=0.56)]. Patient and graft survival were similar for HCV seronegative vs. seropositive recipients of NAT+ organs after the policy change, though this comparison was limited by low sample size (n=26).

*Conclusions: The widespread adoption of NAT and direct acting antivirals have allowed the reliable identification of HCV-viremic donors at high risk of transmitting HCV. Under the current SLK policy, donor NAT+ does not significantly impact patient and graft survival, even among HCV seronegative recipients. However, given low sample size, further study is necessary to delineate the impact of acute HCV transmission on long-term outcomes of the especially vulnerable SLK population.

 border=

 border=

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Samoylova ML, Shaw BI, Kesseli SJ, McElroy L, Patel Y, Sanoff S, Barbas AS. Comparable Outcomes for Simultaneous Liver-Kidney Transplantation with HCV NAT-Positive Donors [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/comparable-outcomes-for-simultaneous-liver-kidney-transplantation-with-hcv-nat-positive-donors/. Accessed May 11, 2025.

« Back to 2020 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences