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Clinical Outcomes of Simplified Once-Daily Immunosuppressive Regimen for Stable Kidney Recipients.

C.-K. Oh,1 S.-J. Kim,2 K. Huh,3 S. Kim,4 J. Jeon,5 S. Han,6 H. Cho,7 Y. Kwon,8 S. Lee,1 Y. Kim.3

1Surgery, Ajou University School of Medicine, Suwon, Republic of Korea
2Surgery, Samsung Medical Center, Seoul, Republic of Korea
3Surgery, Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea
4Surgery, CHA University School of Medicine, Kumi, Republic of Korea
5Internal Medicine, Soon Chun Hyang University Hospital, Seoul, Republic of Korea
6Internal Medicine, Ilsan Paik Hospital, Goyang, Republic of Korea
7Surgery, Ulsan University Hospital, Ulsan, Republic of Korea
8Internal Medicine, Korea University Guro Hospital, Seoul, Republic of Korea

Meeting: 2017 American Transplant Congress

Abstract number: D105

Keywords: Immunosuppression, Kidney transplantation

Session Information

Session Name: Poster Session D: Kidney Immunosuppression: Novel Regimens and Drug Minimization

Session Type: Poster Session

Date: Tuesday, May 2, 2017

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall D1

Aims. Many immunosuppressive drugs are prescribed as twice-daily dosing. Simplified once-daily dosing of the entire drug regimen can improve treatment satisfaction for patients. We examined the safety, efficacy, and treatment satisfaction of a simplified once-daily immunosuppressive regimen using extended-release tacrolimus, sirolimus, and corticosteroids.

Methods. This study was a prospective, multicenter, controlled, cohort trial. Adult kidney transplant patients with a stable renal function were eligible if they had received transplants more than 3 months prior to study enrollment, and were taking tacrolimus. Efficacy failure, safety, and renal function were evaluated until 6 months post-conversion. Measurements of treatment satisfaction were performed.

Results. A total of 160 kidney recipients were in the intention-to-treat (ITT) population. No graft loss and one patient death at home were reported. The incidence of treated biopsy-confirmed acute rejection until 6 months post-conversion was 0.62%. The mean estimated glomerular filtration rate of was not significantly changed (P>0.050)but the 24-hour urinary excretion of protein before conversion was significantly lower (87.1±140.9 mg/day) than that at 6 months post-conversion (206.5±433.5 mg/day, P<0.001) in 140 per-protocol (PP)population. Among the ITT population, overall 95 (59.4%) had a type of adverse event (AE) and 28 patients (17.5%) had a serious AE. The patients demonstrated a significant improvements in treatment satisfaction (P<0.001).

Conclusion. The kidney recipients who received the once-daily immunosuppressive regimen expressed a statistically significant improvement in satisfaction without the additional risks of adverse effects or efficacy failure.

CITATION INFORMATION: Oh C.-K, Kim S.-J, Huh K, Kim S, Jeon J, Han S, Cho H, Kwon Y, Lee S, Kim Y. Clinical Outcomes of Simplified Once-Daily Immunosuppressive Regimen for Stable Kidney Recipients. Am J Transplant. 2017;17 (suppl 3).

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To cite this abstract in AMA style:

Oh C-K, Kim S-J, Huh K, Kim S, Jeon J, Han S, Cho H, Kwon Y, Lee S, Kim Y. Clinical Outcomes of Simplified Once-Daily Immunosuppressive Regimen for Stable Kidney Recipients. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/clinical-outcomes-of-simplified-once-daily-immunosuppressive-regimen-for-stable-kidney-recipients/. Accessed June 2, 2025.

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