Clinical Impact of an ACE Insertion/Deletion and Kinin B2 Receptor +9/-9 Polymorphisms in the Prognosis of Renal Transplantation

C. Amorim, S. Almeida, P. Gomes, R. Bacurau, N. Camara, R. Araujo

UNIFESP, Sao Paulo, Brazil
UNIFESP, Sao Paulo, Brazil
USP, Sao Paulo, Brazil

Meeting: 2013 American Transplant Congress

Abstract number: C1305

There is a consensus in the scientific literature that supports the importance of the kallikrein kinin and renin angiotensin systems in renal physiology, but notably few studies have investigated their importance after renal transplantation. The aim of this study was to investigate the clinical effects of the insertion/deletion polymorphism in the angiotensin-I converting enzyme gene and the +9/-9 polymorphism in the kinin B2 receptor gene in 265 kidney-transplanted patients compared with 443 healthy individuals. Demographic results showed that there is a higher frequency of the D allele (high plasma ACE activity) and +9 allele (lower B2 receptor expression) in transplant patients compared with controls. Furthermore, we also observed a higher frequency of these alleles in patients who had an elevated level of plasma creatinine.

Statistical analysis by Chi-square between the alleles compared to the effect of the control group.
Date	Creatinine	Allele I	Allele D	P
Control (n)		162	268
7 days	< 1.5	72	94	0.929
7 days	> 1.5	85	177	0.001**
7 days	> 3.0	28	69	0.006**
7 days	> 5.0	11	35	0.011*
1 Month	< 1.5	81	131	0.139
1 Month	> 1.5	65	139	0.004**
6 Months	< 1.5	81	127	0.203
6 Months	> 1.5	52	116	0.002**
1 Year	< 1.5	78	110	0.565
1 Year	> 1.5	52	114	0.003**

*p<0.05, **p<0.01.

At day 7 post-transplantation, we found a higher prevalence of individuals with the DD genotype that had an elevated plasma creatinine level. Furthermore, individuals with the DD genotype had a higher chronic allograft and graft loss compared with II patients genotype which showed no loss of graft.

Taken together, our data suggest that the DD genotype is an indicator of an unfavorable prognosis after renal transplantation and could be related to kinin modulation.

To cite this abstract in AMA style:

Amorim C, Almeida S, Gomes P, Bacurau R, Camara N, Araujo R. Clinical Impact of an ACE Insertion/Deletion and Kinin B2 Receptor +9/-9 Polymorphisms in the Prognosis of Renal Transplantation [abstract]. Am J Transplant. 2013; 13 (suppl 5). https://atcmeetingabstracts.com/abstract/clinical-impact-of-an-ace-insertiondeletion-and-kinin-b2-receptor-9-9-polymorphisms-in-the-prognosis-of-renal-transplantation/. Accessed November 22, 2024.

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