Background: It is well known that remaining nephrons after loss of renal tissue showed compensatory hyperfiltration in chronic kidney disease. But in healthy populations without kidney disease, the change of single kidney glomerular filtration rate (sk-GFR) after renal tissue loss has not been fully investigated. The aim of this study was to assess the change of sk-GFR after kidney donation in kidney donors.

Method: Total 74 kidney donors who underwent ^99mTc-DTPA Scintillation-Camera Renography before and after kidney donation were included in this study. We compared remained sk-GFR before and after kidney donation in those patients and investigated the factors that is associated with the level of hyperfiltration of remained single kidney.

Result: The GFR before donation was 109 ml/min/1.73m² and each right and left sk-GFR was 54.6 and 54.2 ml/min/1.73m². Sk-GFR of remaining kidney showed significantly hyperfiltration by 33.6 % after kidney donation (P<0.01 [Pre-nephrectomy 57.9 vs Post nephrectomy 77.5 ml/min/1.73m²]). We divided patients group into three groups according to the level of hyperfiltration (high Δsk-GFR, moderate Δsk-GFR and low Δsk-GFR group). At nephrectomy, low Δsk-GFR group showed larger body weight (P=0.011) and higher sk-GFR of remaining kidney (P=0.005) compared with moderate and high Δsk-GFR group. Multivariable regression analysis revealed body weight (P=0.005) and sk-GFR of (P=0.032) before nephrectomy were independent predictors of different degree of sk-GFR.

Conclusion: In most patients, sk-GFR of remaining kidney showed significant increase due to adaptive hyperfiltration, however in patients with large body size and high sk-GFR of remaining kidney, the adaptive hyperfiltration was insignificant.

« Back to 2013 American Transplant Congress