Better Health-Related Quality of Life in Kidney Transplant Patients over Time Compared with Those in Chronic Kidney Disease Patients at Similar Renal Function

J. Ryu¹, T. Koo¹, K. Oh², C. Ahn³, J. Yang¹

¹Organ transplant center, Seoul National University Hospital, Seoul, Korea, Republic of, ²Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ³Organ Transplant Center
Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of

Meeting: 2019 American Transplant Congress

Abstract number: C102

Keywords: Kidney transplantation, Psychosocial, Quality of life

Session Information

Session Name: Poster Session C: Kidney Psychosocial

Session Type: Poster Session

Date: Monday, June 3, 2019

Session Time: 6:00pm-7:00pm

Presentation Time: 6:00pm-7:00pm

Location: Hall C & D

*Purpose: Both kidney transplantation (KT) and pre-dialysis chronic kidney disease (CKD) patients usually experience mental and physical burdens according to renal functional deterioration. However, change in health-related quality of life (HRQOL) over time in KT patients has not been studied in comparison to that in CKD patients.

*Methods: Adult patients registered in the prospective, KoreaN cohort study for Outcome in patients With KT (KNOW-KT) and Chronic Kidney Disease (KNOW-CKD) between 2011 and 2013 were enrolled. HRQOL scores were assessed using Kidney Disease Quality of Life instrument (KDQOL-SF) and clinical parameters at the point of 0, 2, 4, and 5 year after registration.

*Results: A total of 276 KT and 709 CKD patients were included in the analysis. Both CKD-targeted score (62.1±12.6 at baseline, 75.8±11.6 at 2 yr, 76.6±11.3 at 4 yr, P=0.001) and SF36 score (56.1±18.4 at baseline, 79.6±13.0 at 2 yr, 80.2±12.8 at 4 yr, P=0.001) were improved 2 year after KT and their improvement persisted until 4 years. In contrast, CKD-targeted score and SF36 score were decreased at 5 year-follow-up in CKD patients. Lower GFR, low baseline QOL, diabetes, and low hemoglobin level were independent risk factors for lower SF36 score in KT patients. Employment status and baseline QOL was significantly associated with CKD-targeted score in both KT and CKD patients. At the same renal function, KT patients had significant higher SF36 score than CKD patients at CKD stage 1-3 (80.6±8.9 vs. 76.4±14.8 at stage 1, P=0.000; 80.4±12.9 vs. 74.5±15.0 at stage2, P=0.000; 78.8±12.9 vs. 73.3±16.1, P=0.001), whereas the difference was not significant at stage 4-5 (72.4±19.5 vs. 66.3±18.0, P=0.286). In regard to the CKD-targeted score, KT patients had higher scores than CKD patients only at CKD stage 4-5 (77.4±7.8 vs. 68.4±12.9, P=0.001). In multivariable analysis, KT was an independent determining factor for higher HRQOL (P=0.000).

*Conclusions: KT patients have different HRQOL patterns and higher QOL compared to CKD patients even at the similar renal function.

To cite this abstract in AMA style:

Ryu J, Koo T, Oh K, Ahn C, Yang J. Better Health-Related Quality of Life in Kidney Transplant Patients over Time Compared with Those in Chronic Kidney Disease Patients at Similar Renal Function [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/better-health-related-quality-of-life-in-kidney-transplant-patients-over-time-compared-with-those-in-chronic-kidney-disease-patients-at-similar-renal-function/. Accessed May 12, 2025.

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