Association of Physical Function and Depression Among Kidney-Pancreas Transplant Recipients Using PROMIS CATs

A. Yantsis¹, W. Ghazi¹, A. Norgate¹, M. Sanchez¹, Y. Sun¹, R. Gupta¹, R. Ahuja¹, I. Mucsi²

¹University Health Network, Toronto, ON, Canada, ²Toronto General Hospital, Toronto, ON, Canada

Meeting: 2022 American Transplant Congress

Abstract number: 1184

Keywords: Kidney/pancreas transplantation, Pancreas transplantation, Quality of life

Topic: Clinical Science » Pancreas » 65 - Pancreas and Islet: All Topics

Session Information

Session Name: Pancreas and Islet: All Topics

Session Type: Poster Abstract

Date: Sunday, June 5, 2022

Session Time: 7:00pm-8:00pm

Presentation Time: 7:00pm-8:00pm

Location: Hynes Halls C & D

*Purpose: The number of kidney-pancreas (KP) transplants is increasing accounting for approximately 6% of all kidney transplants in Canada. In addition to kidney failure and dialysis, KP recipients also have the added burden of type 1 diabetes mellitus. Low physical function is associated with depressive symptoms among kidney transplant recipients. However, the relationship between physical function and depression remains unclear among KP transplant recipients (KPTRs). We aim to determine if there is an association between physical function and depression among KPTRs.

*Methods: A cross-sectional, convenience sample of adult KPTRs in Toronto, Canada were assessed using the physical function (PF) and depression item banks of the Patient Reported Outcome Measurement Information System (PROMIS). Item banks were administered using Computer Adaptive Testing (CAT). PROMIS tools were scored using a T-score metric, with a mean score of 50 and SD of 10. Data from patients with insufficient English proficiency, diagnosis of dementia and/or severe acute medical conditions, or those who did not provide informed consent were excluded from analysis. Multivariable linear regression models were generated to assess the association between PF and depression. Covariables included: age, sex, ethnicity, marital status, and Charlson Comorbidity Index (CCI).

*Results: 35 patients (mean (SD) age 52 (9) years, 87% white and 54% male) were enrolled. The mean (SD) PF score was 44 (8) and depression was 51 (7). A weak negative correlation was seen between the PF and depression T scores (r=-0.336, p<0.05). In a multivariable adjusted (age, sex, ethnicity, CCI, and marital status) linear regression model, higher PF predicted lower depressive symptoms scores (B=-0.354, p<0.05; 95% CI: -0.696 - -0.012).

*Conclusions: KPTRs with high physical function scores reported fewer depressive symptoms. Further understanding of the relationship between physical function and depression may be useful to improve quality of life post-transplant.

To cite this abstract in AMA style:

Yantsis A, Ghazi W, Norgate A, Sanchez M, Sun Y, Gupta R, Ahuja R, Mucsi I. Association of Physical Function and Depression Among Kidney-Pancreas Transplant Recipients Using PROMIS CATs [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/association-of-physical-function-and-depression-among-kidney-pancreas-transplant-recipients-using-promis-cats/. Accessed May 6, 2025.

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