Association Between Matrix-gla Protein Levels and Aortic Stiffness in Kidney Transplantation.
1Nephrology, Dialysis and Renal Transplantation, CHU Nord, Saint Etienne, France
2Nephrology and Dialysis, University of Liège, CHU Sart Tilman, Liège, Belgium
3Clinical Chemistry, University of Liège, CHU Sart Tilman, Liège, Belgium
Meeting: 2017 American Transplant Congress
Abstract number: D136
Keywords: Kidney transplantation, Vascular disease
Session Information
Session Name: Poster Session D: Kidney: Cardiovascular and Metabolic
Session Type: Poster Session
Date: Tuesday, May 2, 2017
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
INTRODUCTION
Aortic stiffness due to vascular calcifications is commonly observed among kidney transplant recipients and is considered as a predictive factor of poor events such as cardiovascular events and graft failure. Matrix gla-protein (MGP) is an inhibitor of vascular calficiations. In kidney transplantation, a recent study has shown a significant association between the inactive form of MGP (dephosphorylated and uncarboxylated MGP, dp-ucMGP) and all-cause mortality and transplant failure. However no data showing an association between dp-ucMGP and the risk of vascular calcifications is yet available. The aim of our study was to assess the association between MGP and aortic stiffness in a cohort of kidney transplant recipients.
MATERIAL AND METHODS
We studied the association between the circulating levels of dp-ucMGP, vascular calcifications (Kauppila score) and aortic stiffness (oscillometric method and applanation tonometry) in prevalent kidney transplant recipients. The association was assessed by performing uni and multivariate analysis including parameters such as traditional and non traditional cardiovascular risk factors, pulse wave velocity and estimated GFR (MDRD)
RESULTS
We analyzed 128 patients in two independent centers. The mean age of this cohort was 55.4 ±13.6 years and the mean time since transplantation was 8.3 ±7.7 years.. In univariate analysis, a significant association was observed between MGP and pulse wave velocity (p=0.017). In multivariate analysis, we showed that the factors independently associated with PWV were age (p<0.001), diabetes mellitus (p<0.001), eGFR (p=0.042) and MGP (p=0.048). No association was found between MGP and the Kauppila score.
DISCUSSION
The absence of correlation between MGP and vascular calcifications may be explained by the lack of sensibility of the Kauppila score. These results need to be confirmed among a largest and prospective cohort.
CONCLUSION
Our data suggest the existence of a significant and independent association between MGP levels and elevated aortic stiffness in kidney transplant recipients. More studies need to be conducted to assess the role of MGP as a marker of the cardiovascular risk in kidney transplant.
CITATION INFORMATION: Dinic M, Maillard N, Delanaye P, Krzesinski J.-M, Saint-Remy A.-M, Cavalier E, Mariat C. Association Between Matrix-gla Protein Levels and Aortic Stiffness in Kidney Transplantation. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Dinic M, Maillard N, Delanaye P, Krzesinski J-M, Saint-Remy A-M, Cavalier E, Mariat C. Association Between Matrix-gla Protein Levels and Aortic Stiffness in Kidney Transplantation. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/association-between-matrix-gla-protein-levels-and-aortic-stiffness-in-kidney-transplantation/. Accessed May 11, 2025.« Back to 2017 American Transplant Congress