ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Assessment of Infectious Complications Following ABO-Blood Group Incompatible Renal Transplant

J. Banbury1, T. Loosier1, C. Lin2, K. Gutierrez1

1University of Alabama at Birmingham Hospital, Birmingham, AL, 2Center for Clinical and Translational Science, University of Alabama at Birmingham, Birmingham, AL

Meeting: 2020 American Transplant Congress

Abstract number: B-188

Keywords: Highly-sensitized, Infection, Kidney transplantation, Outcome

Session Information

Session Name: Poster Session B: All Infections (Excluding Kidney & Viral Hepatitis)

Session Type: Poster Session

Date: Saturday, May 30, 2020

Session Time: 3:15pm-4:00pm

 Presentation Time: 3:30pm-4:00pm

Location: Virtual

*Purpose: In response to the ongoing organ shortage, ABO-incompatible (ABOi) renal transplant (RT) provides an alternative option for patients with end-stage kidney disease. Literature suggests that desensitization and higher intensity immunosuppression required for ABOi RT may be associated with increased rates of post-transplant infection. This study aims to compare infectious complications between ABOi and ABO-compatible (ABOc) RT recipients at our institution.

*Methods: This single-center study included recipients of primary RT at UAB Hospital between January 1, 2013, and July 31, 2018. The primary outcome was a composite of bacterial, fungal, viral, opportunistic, and/or surgical site infections. Secondary outcomes include incidence of each infection type, source of infection, inpatient length of stay (LOS), glomerular filtration rate (GFR) and incidence of biopsy-proven acute rejection (BPAR) at 12 months post-transplant.

*Results: A total of 34 ABOi RT recipients were matched 1:2 with ABOc controls based on immunologic risk and transplant characteristics. There was no difference in matched samples except for the calculated panel reactive antibody, which was higher in the ABOi group. All patients received maintenance immunosuppression with tacrolimus, mycophenolate, and steroids. Preliminary results suggest a comparable incidence of composite infections (66.7% vs. 66.7%) with an average rate of 1.53 vs. 1.27 infections per patient for ABOi RT recipients and ABOc controls, respectively. Additionally, there were higher rates of bacterial infections (60.9% vs. 44.7%) and greater LOS (12.5 ± 4.5 days vs. 6.9 ± 2.4 days) in the ABOi group. At 12 months post-transplant, patients with ABOi RT experienced numerically higher rates of BPAR (26.7% vs. 6.7%). Patient survival, graft survival, and GFR were similar between groups. Statistical analysis is ongoing.

*Conclusions: At our center, ABOi RT was associated with a higher average rate of composite infectious complications per patient compared to ABOc matched controls, although the incidence was similar between groups. Preliminary results indicate comparable patient and graft survival at 12 months post-transplant.

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Banbury J, Loosier T, Lin C, Gutierrez K. Assessment of Infectious Complications Following ABO-Blood Group Incompatible Renal Transplant [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/assessment-of-infectious-complications-following-abo-blood-group-incompatible-renal-transplant/. Accessed May 9, 2025.

« Back to 2020 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences