ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Anti-Angiotensin II Type 1-Receptor Antibodies (AT1R-Ab) Induce a Specific Phenotype of Rejection Distinct from HLA Antibody-Mediated Rejection

C. Lefaucheur,1 D. Viglietti,1 O. Aubert,1 A. Philippe,2 P. Halloran,3 A. Loupy,1 D. Dragun.2

1Paris Translational Research Center for Organ Transplantation, Paris, France
2Medical Faculty of the Charité, Berlin, Germany
3Alberta Transplant Applied Genomics Centre, Edmonton, Canada.

Meeting: 2018 American Transplant Congress

Abstract number: 20

Keywords: Antibodies, Endothelial activation, Kidney transplantation, Rejection

Session Information

Session Name: Concurrent Session: Kidney Acute Antibody Mediated Rejection

Session Type: Concurrent Session

Date: Sunday, June 3, 2018

Session Time: 2:30pm-4:00pm

 Presentation Time: 2:42pm-2:54pm

Location: Room Hall 4B

AT1R-Ab have been associated with kidney allograft rejection; however, their ability to induce a specific rejection phenotype, independent of HLA-DSAs, has not been defined.

In a prospective cohort of 881 kidney recipients (2007-2010), we performed systematic screening for AT1R-Ab using quantitative ELISA and HLA-DSAs, together with concomitant allograft biopsy, at the time of any clinical event in the first-year post-transplant and at 1 year post-transplant. The allograft rejection phenotype was assessed by histopathology, immunochemistry for C4d, and allograft gene expression measurement using microarray.

We identified 233/881 (26%) pts with post-transplant AT1R-Ab (>10 U/mL). Compared to AT1R-Ab negative pts, AT1R-Ab positive pts showed increased levels of glomerulitis (p=0.01), peritubular capillaritis (p=0.01), endarteritis (p=0.01), similar level of interstitial inflammation (p=0.66) and tubulitis (p=0.23), and similar prevalence of C4d deposition (p=0.24) and TG (p=0.99). After adjusting for HLA-DSAs, AT1R-Ab were independently associated with glomerulitis (aOR=1.7, p=0.006), peritubular capillaritis (aOR=1.8, p=0.002) and intimal arteritis (aOR=2.1, p=0.01). Among pts with microcirculation inflammation (g+ptc>1) (N=154), AT1R-Ab+/HLA-DSA- pts (N=23) showed increased prevalence of intimal arteritis (39%) and decreased prevalence of C4d positivity (17%) compared to AT1R-Ab-/HLA-DSA+ pts (N=80, 13% and 51%, respectively), AT1R-Ab+/HLA-DSA+ pts (N=31, 16% and 55%, respectively) and AT1R-Ab-/HLA-DSA- pts (N=20, 5% and 10%, respectively) (p<0.001 and p=0.01, respectively). Compared to AT1R-Ab-/HLA-DSA+ pts, AT1R-Ab+/HLA-DSA- pts had increased expression of endothelial cell associated transcripts in allograft, including MEOX2, MEOX1 and FOSB (FC=3.9, 3.0 and 2.7, respectively, p<0.001 for all). Histomolecular rejection phenotype in AT1R-Ab+/HLA-DSA- pts was distinct from that of AT1R-Ab-/HLA-DSA+ pts in unsupervised clustering.

AT1R-Ab are associated with a specific histo-molecular phenotype of kidney allograft rejection, characterized by microvascular and arterial inflammation, expression of endothelial cell associated transcripts and low prevalence of complement deposition in capillaries, independent of HLA-DSAs.

CITATION INFORMATION: Lefaucheur C., Viglietti D., Aubert O., Philippe A., Halloran P., Loupy A., Dragun D. Anti-Angiotensin II Type 1-Receptor Antibodies (AT1R-Ab) Induce a Specific Phenotype of Rejection Distinct from HLA Antibody-Mediated Rejection Am J Transplant. 2017;17 (suppl 3).

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

To cite this abstract in AMA style:

Lefaucheur C, Viglietti D, Aubert O, Philippe A, Halloran P, Loupy A, Dragun D. Anti-Angiotensin II Type 1-Receptor Antibodies (AT1R-Ab) Induce a Specific Phenotype of Rejection Distinct from HLA Antibody-Mediated Rejection [abstract]. https://atcmeetingabstracts.com/abstract/anti-angiotensin-ii-type-1-receptor-antibodies-at1r-ab-induce-a-specific-phenotype-of-rejection-distinct-from-hla-antibody-mediated-rejection/. Accessed June 6, 2025.

« Back to 2018 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences