Purpose: Alkaline phosphatase (ALP) is a marker of bone turnover which is widely used for estimating type of bone turnover in patients with end-stage renal disease (ESRD). Recent data has implicated ALP as an initiator of calcification and pointed it to be associated with atherosclerosis. In this study we aimed to analyze the relationship between renal resistive index and pulse wave velocity and ALP values in a group of renal transplantation patients with good renal function.

Methods: A group of 160 RT recipients (55 years old, 42 female, post transplantation duration median 52 months) were included. Each patient was with a current RT doppler ultrasonography for RRI measurement and pulse wave velocity were recorded. Subjects were grouped according to the post transplant first years' ALP levels as increased ALP (> 120 U/mL, n:42) and normal ALP (n: 118) groups.

Results: Groups were similar in means of demographic characteristics, medications and creatinine, calcium, phosphorus, CaxP and PTH and creatinine clearance levels according to the first years results. Patients with increased ALP levels also had increased RRI (0.71 ± 0.06 vs 0.67 ± 0.08, p: 0.022) and pulse wave velocity measurements (8.6 ± 2.4 vs 6.8 ± 1.3, p: 0.003). A follow-up data of 3 years revealed that patients with increased ALP had higher creatinine (p: 0.03) and lower GFR levels (p: 0.02).

Conclusion: In conclusion, posts transplant high ALP level correlates with atherosclerosis and high renal resistive index. Additionally, ALP can be a new prognostic follow-up marker in terms of atherosclerosis and patients whose levels >120 IU/L show poor long term renal graft function.

CITATION INFORMATION: Sezer S, Tutal E, Bal Z, Demirci B, Haberal M. Alkaline Phosphatase a New Marker for Graft Outcome and High Pulse Wave Velocity in Renal Transplant Recipients. Am J Transplant. 2016;16 (suppl 3).

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