*Purpose: Clinical trials have demonstrated the feasibility and reproducibility of uterus transplantation (UTx) to treat absolute uterine factor infertility. Successful live births have resulted from both deceased and living donor uterus transplantation, with more successful recipient pregnancies after living uterus donation. The utilization of living uterus donors for this quality of life-enhancing transplantation remain controversial because of the risks that living uterus donation entails. This study aimed to assess the perceptions of living uterus donors regarding their motivations for donation, perceptions of informed consent, and the value of the uterus donation experience.

*Methods: Semi-structured interviews were conducted by phone or in-person of living uterus donors from a single center. Qualitative data were analyzed for themes.

*Results: Seventeen of 18 uterus donors consented to participate and completed an interview (94% participation rate). 16/17 were non-directed, and one was directed. Participants were primarily motivated to donate their uterus to give another woman the experience of pregnancy, all felt that informed consent was both accurate and adequate, and all believed that uterus donation had been worthwhile. (Figure 1)

*Conclusions: Uterus donors were highly motivated, well informed, and perceived uterus donation as worthwhile. Our study supports that claim that living donation should remain an option for UTx. More research is needed to determine both the long-term perceptions of uterus donors as well as how donor-recipient relationships and recipient outcomes impact experiences with uterus donation.

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