*Purpose: To summarize the long-term safety of different levels of GFR of retained kidney among living-related donors.Health status,postoperative recovery,and postoperative complications were compared and analyzed.

*Methods: A total of 512 living donors in our kidney transplantation center from 1999 to 2018 were enrolled into this study.The donors were divided into three groups according to donor retained kidney GFR level(GFR<45ml/min;45ml/min≤GFR<50ml/min;GFR≥50ml/min).The predonation retained kidney GFR was measured by 99mTC-DTPA.The recovery of kidney function and complications of the donor after surgery were evaluated.

*Results: 163 donors were excluded because of incomplete data.A total of 349 cases were included in this study,All donors were healthy with no kidney failure.The longest postoperative follow-up time was 20 years,The median follow-up time was 8.3 years.No significant difference was observed in the incidence of postoperative hypertension and urine protein among the three groups of donors.The postoperative Scr of GFR≥50ml/min group at 1 week,1month,3 months,3 years,5 years,10 years was higher compared with the GFR<45ml/min group,and the difference of Scr and eGFR at 1 week,3 months was significantly different(P<0.05).The GFR(measured by 99mTC-DTPA)of three groups of donors more than 10 years were not significantly different.

*Conclusions: Living-related donors have good long-term safety after donation.For donors with preoperative total GFR≥80ml/min,the level of retained renal GFR affects the donor’s early renal function ,while donors with high retained kidney GFR have higher eGFR level and lower Scr level ,but the donor’s retained renal GFR level does not affect the donor Long-term renal function and complication rate after donation.

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