*Purpose: The PROMIS (Patient-Reported Outcomes Measurement Information System) Global-10 survey has been used to assess HRQoL in population surveys and studies including patients with chronic medical conditions but not in patients with chronic kidney disease (CKD). Here we compare HRQoL between kidney transplant recipients (KTR) and patients on dialysis using the PROMIS Global-10 survey.

*Methods: A cross-sectional convenience sample of adult KTRs and patients on dialysis completed the 10 item PROMIS Global-10 which yields a Global Physical Health (GPH) and a Global Mental Health (GMH) score. Sociodemographic and clinical characteristics were also collected. The two-sample t-test and multivariable linear regression were used to compare HRQoL between groups. Multiple imputation by chained equations was used to handle missingness.

*Results: 355 patients (mean(SD) age 55(15) years, 61% male, 52% White, and 61% transplanted) were enrolled. Patients on dialysis vs KTRs were older (mean[SD] age 62[14] vs 51[14] years), less likely to be White 34% vs. 63%), and to have more than 12 years of education (43% vs. 73%.); p<0.001 for all. Compared to patients on dialysis, KTRs had significantly higher GPH (47[9] vs. 43[11], p<0.001) and GMH (49[10] vs 47[11], p= 0.048). The proportion of patients with “impaired HRQoL” (GPH or GMH <45, 5-point, i.e. half SD below general population mean, i.e. 50), was lower among KTRs (48% vs 71%, p<0.001, and 35% vs 48%, p=0.016 for GPH and GMH, respectively). After adjusting for age, sex, marital status, ethnicity, income, education, and comorbidity in linear regression, GPH (b=2.52, 95%CI: 0.1 - 4.9, p= 0.038) but not GMH (b=0.90, 95%CI: -1.8- 3.6, p= 0.504) was significantly higher in KTRs.

*Conclusions: The PROMIS Global-10 GPH but not GMH was higher among KTRs compared to patients on dialysis. Further studies are needed to assess the value of this brief, widely validated tool in assessing HRQoL among patients with CKD.

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