New-Onset Diabetes and Glucose Regulation Are Significant Determinants of Left Ventricular Hypertrophy
Department of Nephrology, Baskent University, Ankara, Turkey
Department of Internal Medicine, Baskent University, Ankara, Turkey
Department of Nephrology, Baskent University, Istanbul, Turkey
Department of General Surgery, Baskent University, Ankara, Turkey
Meeting: 2013 American Transplant Congress
Abstract number: 335
Purpose: . Arterial stiffness has a pivotal role in the genesis of high blood pressure (SBP), increased left ventricular hypertrophy (LVH), and consequently CV mortality. New-onset diabetes after transplantation is associated to increased risk of cardiovascular (CV) events. Both LVH and arterial stiffness are independent determinants of CVD in patients with ESRD. The aim of this study is to evaluate the relationship between post-transplant new-onset diabetes and arterial stiffness LVMI in kidney transplant recipients.
Participants: One hundred and fifty nine kidney transplant recipients (57 patients with new onset diabetes) with minimum one year post transplant period were enrolled into the study.
Methods and Analysis: All patients’ demographic, clinical and biochemical parameters including pulse wave velocity (PWv) levels and echocardiographic measurements were analyzed. PWv was determined from pressure tracing over carotid and femoral arteries. Left ventricular mass was calculated according to the Devereux formula and indexed for body surface area to give LVMI.
Results: Patients were divided into two groups according to LVMI: LVMI > 130g/m2 (n:57) and LVMI ≤130g/m2 (n:102).The percentage of patients with high LVMI (>130g/m2) was significantly higher in patients with post-transplant new-onset diabetes (63.2% vs 21.6%, p:0.0001). Patients with new onset diabetes were significantly older than patients without diabetes. The body mass indices of patients with new onset diabetes was significantly higher (25.0±5.5 vs 27.5±4.1, p:0.002). In patients with new onset diabetes, serum HbA1c levels are significantly correlated with LVMI (p: 0.05). In patients with high LVMI; serum HbA1c levels (7.36±1.5 vs 6.68±1.3, p:0.001), systolic and diastolic blood pressures (p:0.0001) and age (p:0.007) were significantly higher than in patients with low LVMI. Linear regression analysis revealed that HbA1c was the major determinant of LVMI (P:0.026, b:0.361).
Conclusions: Post-transplant increased LVMI is associated with new-onset diabetes after renal transplantation. HbA1c is the major determinant of LVMI, so strict control of serum glucose levels is essential for preventing cardiovascular disease.
To cite this abstract in AMA style:
Uyar MErkmen, Sezer S, Bal Z, Tutal E, Demirci BGurlek, Hasdemir E, Colak T, Acar FOzdemir, Haberal M. New-Onset Diabetes and Glucose Regulation Are Significant Determinants of Left Ventricular Hypertrophy [abstract]. Am J Transplant. 2013; 13 (suppl 5). https://atcmeetingabstracts.com/abstract/new-onset-diabetes-and-glucose-regulation-are-significant-determinants-of-left-ventricular-hypertrophy/. Accessed November 23, 2024.« Back to 2013 American Transplant Congress