Incidence of Urinary Tract Infections in Kidney Transplant Recipients Receiving Alternate Antimicrobial Prophylaxis Regimens
D. Quan1, J. Phillips1, E. Chiang1, V. Kuo2
1UCSF Health, San Francisco, CA, 2UC Davis, Davis, CA
Meeting: 2020 American Transplant Congress
Abstract number: D-166
Keywords: Bacterial infection, Infection, Kidney transplantation, Prophylaxis
Session Information
Session Name: Poster Session D: Kidney Infectious Excluding Polyoma & Viral Hepatitis
Session Type: Poster Session
Date: Saturday, May 30, 2020
Session Time: 3:15pm-4:00pm
Presentation Time: 3:30pm-4:00pm
Location: Virtual
*Purpose: Urinary tract infections (UTI) occur frequently in renal transplant (RT) recipients. Antimicrobial prophylaxis may help prevent UTI early post RT. Trimethoprim/sulfamethoxazole (TMP/SMX) is the standard of care (SOC) to prevent Pneumocystis jirovecci pneumonia and UTI. Patients intolerant to TMP/SMX receive an alternative regimen with antimicrobial activity consisting of either cephalexin or ciprofloxacin for 1 month. The purpose of this study is to evaluate the efficacy of alternate antimicrobial prophylaxis regimens to prevent UTI in RT recipients.
*Methods: This is a single-center retrospective cohort study of patients ≥18 years old who received a RT between June 1, 2015 and June 30, 2018. Multi-organ transplant recipients, HIV-infected individuals, and patients who received antimicrobials for other infections prior to procedure or post-transplantation were excluded. The SOC group received TMP/SMX daily for the first month. Patients in the alternate group received either cephalexin or ciprofloxacin for the first month. The primary outcome was the incidence of UTI 1 month post RT. Secondary outcomes included UTI incidence at 2 and 3 months post-transplant, incidence of recurrent UTI, median time to first UTI, and pathogens and susceptibility patterns.
*Results: A total of 220 patients were analyzed (200 in SOC and 20 in alternative). There was a lower incidence of UTI at month 1 in the alternative group compared to SOC (5% vs 12.5%, p=0.32). The UTI incidence at months 2 and 3 were (20% vs. 7.5% p=0.058, and 30% vs 1%, and p<0.001) respectively. There was a higher incidence of recurrent UTI post-RT within 3 months (15% vs. 1.5%, p=0.012) and a longer median time to first UTI in the alternative group (46 days vs. 17 days, p=0.003). Escherichia coli (E. coli) was the most common pathogen found in the SOC group. Resistance to TMP/SMX was observed for all E. coli, Enterobacter and Klebsiella isolates in the SOC group. Antimicrobial resistance patterns were consistent with our institution’s antibiogram.
*Conclusions: There was no statistical difference in the incidence of UTI between the SOC or alternative regimens during the first month. However, there was a higher incidence of recurrent UTI within 3 months of KT following discontinuation of prophylaxis as well as a longer time to first UTI with the alternative regimens suggesting an antimicrobial suppressive effect of the alternative antimicrobials.
To cite this abstract in AMA style:
Quan D, Phillips J, Chiang E, Kuo V. Incidence of Urinary Tract Infections in Kidney Transplant Recipients Receiving Alternate Antimicrobial Prophylaxis Regimens [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/incidence-of-urinary-tract-infections-in-kidney-transplant-recipients-receiving-alternate-antimicrobial-prophylaxis-regimens/. Accessed November 22, 2024.« Back to 2020 American Transplant Congress