Periphery Blood ddcfDNA Can Significantly Differentiate Acute Humoral Rejection from Banff’s Type I Acute Rejection in Kidney Transplantation
1Kidney Disease Center, First Affiliated Hospital of Zhejiang University, Hangzhou, China, 2Organ diagnosis company, Suzhou, China, 3Organ Diagnosis Company, Suzhou, China
Meeting: 2019 American Transplant Congress
Abstract number: C153
Keywords: Kidney transplantation, Rejection
Session Information
Session Name: Poster Session C: Kidney: Acute Cellular Rejection
Session Type: Poster Session
Date: Monday, June 3, 2019
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall C & D
*Purpose: Cell free DNA(cfDNA) was widely used in field of cancer and obstetric care. Alloantigens was existed in Organ transplantation, so donor derived cfDNA(ddcfDNA) was now reported in the kidney transplantation. Now we aimed to explore the ddcfDNA level in different type of acute rejection in kidney transplantation.
*Methods: From December 2017 to August 2018, 10 biopsy-proved Banff’s type I acute rejection and 8 biopsy-proved acute humoral rejection kidney transplant patients were included in this study. When the patients experienced biopsy-proved rejection, periphery blood was obtained to identify the ddcfDNA level.
*Results: HLA mismatch was 1.8±1.1 in type I acute rejection group, 2.5±0.9 in acute humoral rejection group, p=0.179; Donor type(DCD/living) was 6/4 in the former group and 4/4 in the latter group, p=0.671; Year of patient age was 33.7±11.5 in type I acute rejection group, and 32.8±9.4 in acute humoral rejection group, p=0.853; Sex (male/female) was 3/7 in former group, 6/2 in latter group, p=0.058; The percentage of peripheral ddcfDNA level was 0.78±0.51 in type I acute rejection group, significantly lower than that 2.04±0.84 in acute humoral rejection group, p=0.001.
*Conclusions: Acute humoral rejection had significantly higher periphery ddcfDNA level when compared to type I acute rejection in kidney transplantation.
To cite this abstract in AMA style:
Wang R, Jiang T, Shen J, Ge J, Lei W, Yang X, Deng H, Kong W, Zhou J. Periphery Blood ddcfDNA Can Significantly Differentiate Acute Humoral Rejection from Banff’s Type I Acute Rejection in Kidney Transplantation [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/periphery-blood-ddcfdna-can-significantly-differentiate-acute-humoral-rejection-from-banffs-type-i-acute-rejection-in-kidney-transplantation/. Accessed May 12, 2025.« Back to 2019 American Transplant Congress