*Purpose: Opioid use after kidney transplant has been shown to be a risk factor for chronic opioid use, which leads to an increased risk of mortality. The purpose of this study was to evaluate the early impact of a multimodal pain regimen and education quality improvement program on opioid use after kidney transplant two months after implementation.

*Methods: This was a retrospective, single-center analysis of post-operative opioid use, comparing the average daily MME of the patients who received education on opioids and a multimodal pain regimen (preoperative TAP/QL block, scheduled APAP and gabapentin) compared to a historical control group.

*Results: Despite having no differences in pre-transplant opioid exposure (Table 1), daily and overall inpatient opioid utilization was significantly reduced in the multimodal pain protocol cohort (38.6 vs 8.0 MME/day; p<0.001); 5% of patients in the multimodal pain protocol cohort were discharged with an opioid prescription, compared to 96% of controls (p<0.001) (Table 2, Figure 1).

*Conclusions: Our early results demonstrate that a multimodal pain protocol can effectively and dramatically reduce short-term opioid utilization in kidney transplant recipients. Follow-up to determine changes in long-term opioid utilization is warranted.

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