Aims: Describe the outcomes of very old kidney recipients of grafts from very old donors. Identify pretransplant clinical factors associated with graft and recipient survival.

Methods: Retrospective analysis of clinical outcomes in elderly patients (≥70 years) that received a kidney transplant from a very old donor (≥70 years) at our institution from October 2004 to December 2013 (n= 155).

Results: Median age of donors and recipients was 77 (74-79) and 75 (73-78) years, respectively. The 3-year and 5-year patient survival was 73.1% and 67.1%, respectively. Death censored graft survival was 83.4% at year 3 and 80.8% at year 5. Median serum creatinine at year 5 was 1.55 (1.23-1.89) mg/dl, with a median eGFR of 40ml/min/1.73m². The main identifiable cause of death was infections (34.3%) while the main cause of graft loss was death with a functioning graft (47.1%). History of cerebrovascular disease in the recipient was associated with an increased risk of recipient mortality (HR 5.12, p=0.027), while history of diabetes in the recipient was associated with increased risk of graft loss (HR 4.40, p=0.0001).

Conclusions: Kidney transplantation from very old donors in patients over 70 years offers a survival advantage over staying on dialysis with an acceptable renal function in the mid-term. Infections are an important cause of death in very old kidney recipients. History of cerebrovascular disease in the recipient was associated with an increased risk of recipient mortality. History of diabetes in the recipient was associated with increased risk of graft loss.

CITATION INFORMATION: Trujillo H., García A., Cavero T., Redondo B., Moliz C., Bada T., González E., Praga M., Andrés A. Outcomes of Very Old Kidney Recipients of Grafts from Very Old Donors Am J Transplant. 2017;17 (suppl 3).

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