The Incidence and Risk Factors for Non – Adherence to Medical Treatment among Patients after Kidney Transplantation

T. Mashraki,^1,2,3 B. Rozen-Zvi,^1,4 E. Mor,^2,4 A. Yussim,^1,2 C. Avry,^1,4 R. Rahamimov.^1,2,3

¹Nephrology and Hypertension, Rabin Medical Center, Petach Tikva, Israel
²Transplantation, Rabin Medical Center, Petach Tikva, Israel
³Faculty of Health Science, Ariel University Center of Samaria, Ariel, Israel
⁴Sackler Faculty of Medicine, Tel- Aviv University, Tel- Aviv, Israel.

Meeting: 2018 American Transplant Congress

Abstract number: B197

Keywords: FK506, Kidney transplantation, Psychosocial

Session Information

Session Name: Poster Session B: Kidney Psychosocial

Session Type: Poster Session

Date: Sunday, June 3, 2018

Session Time: 6:00pm-7:00pm

Presentation Time: 6:00pm-7:00pm

Location: Hall 4EF

Background: Nonadherence to medical treatment is an important risk factor for acute rejection and graft loss. In this study we sought to determine the prevalence and risk factors for non-adherence among kidney transplant recipients in our follow up clinic and to check the association between non-adherence to medical treatment and high time weighted coefficient of variability (TWCV) of Tacrolimus trough blood levels.

Patients and methods: 298 consecutive kidney graft recipients fulfilled the Simplified Medication Adherence Questioner (SMAQ).A patient was classified as non-adherent if he/she responded to any of the questions with a non-adherent answer, and in terms of quantification, if the patient has lost more than two doses during the last week or has not taken the medication for more than two complete days during the last three months.

RESULTS: 147(49.3%) of patients were found to be non-adherent. non-adherence rate was 57.0% among younger patients (younger than the median age) in comparison to 41.7% among older patients (p=0.008), 55.5% in patients more than one year after transplantation in comparison to 31.5 % in patients within the first year (p<0.001), other factors associated with non-adherence by univariate analysis were smoking status and lack of education. By multivariate logistic regression analysis, younger age, longer time from the transplantation, current smoking and first transplantation were associated with non-adherence.

Gender, marital status and occupation were not found to be associated with non-adherence.

Non-adherence was not correlated with higher TWCV in Tacrolimus trough levels

Conclusion: almost half of patients were found to be non-adherent to medical treatment. Non-adherence was associated with younger age, longer time since transplantation, first transplantation and current smoking status. No correlation was noted between tacrolimus variability and non-adherence.

CITATION INFORMATION: Mashraki T., Rozen-Zvi B., Mor E., Yussim A., Avry C., Rahamimov R. The Incidence and Risk Factors for Non – Adherence to Medical Treatment among Patients after Kidney Transplantation Am J Transplant. 2017;17 (suppl 3).

To cite this abstract in AMA style:

Mashraki T, Rozen-Zvi B, Mor E, Yussim A, Avry C, Rahamimov R. The Incidence and Risk Factors for Non – Adherence to Medical Treatment among Patients after Kidney Transplantation [abstract]. https://atcmeetingabstracts.com/abstract/the-incidence-and-risk-factors-for-non-adherence-to-medical-treatment-among-patients-after-kidney-transplantation/. Accessed November 23, 2024.

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