Introduction:Among living kidney donors at risk of CKD at 1 year after nephrectomy, some donors remain with poor renal function while many show delayed recovery of renal function afterwards. We studied the factors related to delayed recovery of renal function in patients with CKD at 1 year after nephrectomy.

Method: Patients who underwent donor nephrectomy during March, 2006 to April, 2014 with a follow up creatinine study at 1 month, 6 months, 1 year, and for more than after 3 years of follow-up were included in the study.

Result: 83 donors were included in the study, and the eGFR was followed during a median follow-up of 62.0(IQR 48.9~83.1) months. Those who recovered eGFR of more than 5ml/min/1.73m² were included in the recovery group(48, 57.8%), and those who didn't were included in the non-recovery group(35, 42.2%). The pre-operative and 1-year follow-up eGFR was not significantly different in the two groups, and the maximum eGFR after 3-years was higher in the recovery group (68.68(IQR 61.81~75.64) vs 55.63(IQR 51.73~58.29), p<0.001). The recovery group was more likely to have a history of hypertension(4.2% vs 20%, p=0.032), have lower BMI(24.11(IQR 22.04~25.20) vs 25.25(IQR 23.23~26.44) kg/m², p=0.01), and have lower preoperative uric acid(4.7(IQR 3.8~5.4) vs 5.3(IQR 4.4~6.2) mg/dL, p=0.031). After multivariate logistic regression analysis history of hypertension(p=0.022, OR 0.131) and uric acid level(p=0.036, OR 0.641) remained as significant factors.

Conclusion: While 30.2% donors were with CKD at 1-year after nephrectomy, 57.8% showed delayed recovery of renal function. Those with a history of hypertension and high pre-operative uric acid levels are less likely to recovery renal function and require close follow-up.

CITATION INFORMATION: Na J., Park J., Yoon M-.G., Lee H., Yoon Y., Huh K., Kim M., Kim S., Kim Y., Han W. Delayed Recovery of Renal Function after Donor Nephrectomy Am J Transplant. 2017;17 (suppl 3).

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