Introduction: The need to implement the pool of donors has led to the use of organs from older donors, as has been described in several studies. The objective of our work was to study the long-term survival in recipients of elderly donors, and secondarily, to study the initial and long-term renal function.

Material and methods: The inclusion period was from January 2010 to December 2016. There were 530 patients from cadaveric donors. 462 of them were in encephalic death. We have analyzed donor and recipient age, HLA compatibilities, cold ischemia time, acute rejection, initial graft function and during follow-up and survival of patients and graft. The analysis was perfromed according to donor age in 3 groups: <55 years old, 55-75 and > 75. Alcest statistical program was used for the analysis.

Results: The first group was constituted by 116 patients, the second by 177 and the third by 169. The mean age was 45±11,6, 53±11,8 and 63,8± 8,8 years (p <0.01). Donor age was 43±10, 65±5 and 79±7 years (p <0.01). The HLA incompatibilities were 2,8±1, 3,1± 0,9 and 2,9 ± 0,9 (p = 0.06). Cold ischemia time was 16±5, 17,9± 5 and 19 ± 3,5 hours (p <0.001). The days until the first creatinine decrease were 2,6±4,1 (0-29), 3,5± 6,8 (0-60), 3±5 (0-35) (p <0.01). Serum creatinine at the first month was 1,7±1,2, 1,8±0,8 and 2,1±0,8 mg/dl (p <0,01); serum creatinine at year 1,3±0,4, 1,6± 0,7 and 1,8±0,6 (p <0,001) and at 5 years 1,3± 0,46, 1,7±0,9 and 1,8±0,6 (p <001). The survival analysis of Kaplan-Meier showed a graft survival rate at one year among patients with a donor younger than 55 years of 91%, among patients with donors between 55 and 75 years old of 86%, and in the group of donors over 75 years of age 83%. At 5 years, survival was 86%, 69%, and 67%. The patient survival at one year was 97, 94 and 96% and at 5 years of 97, 87 and 85%.

Conclusions: In our experience the renal recipients who had very old donors have a behavior similar to those of the group aged between 55 and 75 years. Grafts from young donors have better survival.

CITATION INFORMATION: Jiménez Alvaro S., Fernández Rodriguez A., Galeano Alvarez C., Elías Treviño S., Burgos J., Liaño García F. Evolution of Very Old Donor Grafts Am J Transplant. 2017;17 (suppl 3).

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