Introduction: The additive or synergistic effects of multiple co-morbidities at the time of listing on transplant survival is still unclear. Objective scoring systems predicting post-transplant outcomes are needed. We independently tested the applicability of the Hennepin scoring system.

Methods: 274 deceased kidney transplantation recipients (mean age 51.3∓14.9 years, F/M:113/161: 29.3% AA, 26.6% with diabetes) transplanted between 2006-15 were included. Age, functional status, cardiovascular co-morbidities, dialysis and diabetes status, were determined at the time of listing. Serious adverse outcome defined as mortality, graft loss, MI or stroke, ICU stay > 2 weeks/ICU readmission, or care at a long-term care facility >2 months (within 1 year post-transplant). Patients were stratified into 4 risk groups:low (score 0-1),average (2-4),above average (5-7), high (8+).

Results: A total of 49 events occurred in 43 patients within the 1st year. The incidence of severe adverse events 1-year post-transplant was 17.8 %. While only 8% of patients were stratified into the high-risk group they accounted for 28% of the severe adverse outcomes, a patient in this group having a > 50% chance of a severe adverse outcome. The Hennepin transplant risk score showed moderately good discrimination for severe adverse events (c- statistics:0.648).

Discussion: These results provide external validation of the Hennepin score for discriminating short-term post-transplant morbidity for kidney transplantation recipients. Stratifying risk at the time of transplantation will allow for better allocation of deceased organs.

CITATION INFORMATION: Velioglu A., Vijayan M., Shin H., Perry J., Chandraker A. External Validation of Hennepin Transplant Risk Score for Prediction of Short-Term Mortality and Morbidity after Deceased Kidney Transplantation Am J Transplant. 2017;17 (suppl 3).

« Back to 2018 American Transplant Congress