Introduction: Renal transplantation is the preferred option for patients with end stage renal disease (ESRD). It provides better quality of life and lower mortality rates when compared to dialysis. However, nephrectomy for kidney donors is not free of risks as it exposes them to surgical hazards and potential increased incidence of ESRD. The aim of this study is to assess potential risk factors that can affect full compensation of kidney function in living kidney donors

Methodology: Renal graft function of 172 living kidney donors who underwent nephrectomy from 1^st January 2003 to 31^st December 2013 in a single Centre were retrospectively reviewed using a computerised database. Donors were followed up for 6 years post-nephrectomy. Donors were grouped into 2 groups according to eGFR post donation; case group (n=74,m=36,f=38; eGFR <60 mL/min/1.73 m2)and control group (n=98,m=37,f=61; eGFR >60 mL/min/1.73 m2). The following measures were collected: age, gender, mean creatinine, mean eGFR, mean BMI, number of antihypertensive medications and urine PCR pre and post-nephrectomy.

Results: Mean eGFR in case and control groups pre-nephrectomy were 70.1 and 76.1 mL/min/1.73 m2 respectively. At 2 years post-nephrectomy, mean eGFR in the case group was 49 mL/min/1.73 m2 and 62 mL/min/1.73 m2 in the control group .Kaplan-Meier survival analysis showed that the median time taken for eGFR in kidney donors post-nephrectomy to reach 60 mL/min/1.73 m2 was 419 days. Univariate analysis showed that age>50 (p=0.0345), diagnosis of hypertension (p=0.0289, 00391), high pre-nephrectomy serum creatinine levels (p<0.001), low eGFR (P=0.0137) and lower range of normal of isotopic GFR (p=0.0023) values pre-nephrectomy are predictors of failure of full renal function compensation. Multivariate analysis showed that old age (p=0.0264), male gender (p=0.0123), high pre-nephrectomy serum creatinine values (p=0.0305) and low pre-nephrectomy eGFR are significantly associated with failure of full renal function compensation.

Conclusion: Risk factors that predict whether a kidney donor achieves full compensation of kidney function post-nephrectomy are age, gender, pre-donation serum creatinine levels and eGFR.

CITATION INFORMATION: Choong J, Ali H, Ahmed A. Predictors of Renal Function Compensation in Live Donor Nephrectomy. Am J Transplant. 2017;17 (suppl 3).

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