Controlled Donation After Circulatory Death (cDCD) Donors May Become Similar to Brain Death Donors (DBD).

C. Antoine,¹ M. Videcoq,² B. Riou,³ D. Dorez,⁴ G. Cheisson,⁵ L. Martin-Lefèvre,⁶ L. Durand,¹ E. Savoye,¹ G. Karam,² B. Barrou.³

¹Agence de la Biomedecine, Saint Denis La Plaine, France
²University Hospital, Nantes, France
³University Hospital La Pitie, Paris, France
⁴Hospital, Annecy, France
⁵University Hospital, Kremlin Bicetre, France
⁶Hospital, La Roche Sur Yon, France

Meeting: 2017 American Transplant Congress

Abstract number: C25

Keywords: Donors, Kidney transplantation, non-heart-beating, Outcome, Warm ischemia

Session Information

Session Name: Poster Session C: Deceased Donor Issues II: DCD, DGF, AKI, En-Bloc

Session Type: Poster Session

Date: Monday, May 1, 2017

Session Time: 6:00pm-7:00pm

Presentation Time: 6:00pm-7:00pm

Location: Hall D1

Since 2014 in France, we started a cDCD program characterized by the introduction of normothermia regional perfusion (nRP) and selection criteria as donor age ≤65 y, functional warm ischemia time (fWIT) <30 min (liver), <90 min (lung), <120 min (kidney), and short cold ischemia times (CIT).

Potential recipients were recipients awaiting a 1^st transplant.

Out of 101 potential cDCD donors (2015-10/2016), 50 have been retrieved, mean age 49 y. Causes of death are mainly hypoxic brain damage (59%) and trauma/head injury (27%). Mean fWIT are 36 min (kidney only), 22 min (liver and kidney). nRP was used in all utilized donors, the mean circulatory arrest delay was 25 min. Average renal CIT was 10.4h.Mean fWIT are 36 min (kidney only), 22 min (liver and kidney). Average renal CIT was 10.4h.

The aim of this study was to compare primary non function (PNF), delayed graft function (DGF) and length of stay in hospital after 1st single kidney transplantation (KTR) with 2 types of donors: cDCD (92 KTR from 12/2014 to 10/2016) and donors after brain death (DBD) aged 18-65 y (5176 KTR from 1/2013 to 8/2016). Rate of PNF (1 vs 2.5%), mean creatinine (164 vs 179 [mu]mol/l) and renal clearance (49 vs 46 ml/mn) at discharge are similar. DGF rate (9% vs 19%) and dialysis number in case of DGF are significantly lower in case of cDCD.

24 liver transplants and 1 bilateral lung transplant were also performed without EAD and with excellent transplant outcomes.

These good results ensue from a consensual national protocol, which aims were to limit warm ischemia times and injuries, thanks to the use of nRP, optimal graft preservation and recipient selection. cDCD donors might represent a source of kidneys giving results equivalent to SCD donors!

CITATION INFORMATION: Antoine C, Videcoq M, Riou B, Dorez D, Cheisson G, Martin-Lefèvre L, Durand L, Savoye E, Karam G, Barrou B. Controlled Donation After Circulatory Death (cDCD) Donors May Become Similar to Brain Death Donors (DBD). Am J Transplant. 2017;17 (suppl 3).

To cite this abstract in AMA style:

Antoine C, Videcoq M, Riou B, Dorez D, Cheisson G, Martin-Lefèvre L, Durand L, Savoye E, Karam G, Barrou B. Controlled Donation After Circulatory Death (cDCD) Donors May Become Similar to Brain Death Donors (DBD). [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/controlled-donation-after-circulatory-death-cdcd-donors-may-become-similar-to-brain-death-donors-dbd/. Accessed November 22, 2024.

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