Impact of Pediatric Lung Transplant on Quality of Life Outcomes.
1Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada
2Division of Respiratory Medicine, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada
3Program in Physiology and Experimental Medicine, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada
4Transplant and Regenerative Medicine Centre, The Hospital for Sick Children, Toronto, ON, Canada
5Factor-Inwentash Faculty of Social Work, University of Toronto, Toronto, ON, Canada
6Canadian National Transplant Research Program, Toronto, Canada
Meeting: 2017 American Transplant Congress
Abstract number: B257
Keywords: Quality of life
Session Information
Session Name: Poster Session B: Lung Transplantation Poster Session
Session Type: Poster Session
Date: Sunday, April 30, 2017
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
Purpose: Considerable debate within the transplant community over the last decade has focused on survival benefits following lung transplant (LTx) in children. This discussion has largely concentrated on medical outcome data and has brought to light a research agenda that looks beyond medical outcome data to quality of life (QoL) outcomes. The primary objective of this study was to examine the impact of LTx on the QoL of pediatric recipients.
Methods: LTx recipients aged 8–17 years and their parents were recruited from a Canadian transplant centre. Participants completed the Pediatric Quality of Life Inventory 4.0 (PedsQL) pre-LTx and two times post-LTx. The 23-item PedsQL is a comprehensive and validated instrument for measuring health-related QoL in children and adolescents and encompasses physical, emotional, social and academic functioning. Pre-LTx QoL scores were compared with initial assessment scores post–LTx and changes in QoL over time were described. Correlations between self- and proxy-reports and comparisons against normative data were discussed.
Results: Ten pediatric LTx recipients (6 male, mean age = 13.3) and their parents were enrolled. Pre- and post-LTx total scores differed significantly for both self-report and proxy-report (p = 0.005 for each), which remained consistent at a second assessment post-LTx (children: p = 0.018; parents: p = 0.028) (Table 1). Post-LTx self-report scores approached scores of healthy children in the domains of physical functioning, psychosocial health summary score and total score, and exceeded scores of healthy children on emotional functioning.
Conclusions: Findings provide a unique understanding of the experiences of pediatric LTx recipients and highlight the importance of considering QoL outcomes when exploring pediatric LTx as a treatment option. Future research should explore long-term QoL outcomes post-LTx and examine standardized integration of patient-reported outcomes into clinical practice.
CITATION INFORMATION: Lazor T, Grasemann H, Solomon M, Anthony S. Impact of Pediatric Lung Transplant on Quality of Life Outcomes. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Lazor T, Grasemann H, Solomon M, Anthony1 S. Impact of Pediatric Lung Transplant on Quality of Life Outcomes. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/impact-of-pediatric-lung-transplant-on-quality-of-life-outcomes/. Accessed May 19, 2025.« Back to 2017 American Transplant Congress