The incidence of recurrent lupus nephritis varies among different ethnic groups. We performed a single center retrospective analysis of recurrent lupus nephritis in kidney transplant recipients of diverse ethnicitiies.

Methods: All patients with ESRD due to lupus nephritis (LN) who underwent kidney transplantation from 1/1/2001 to 12/31/2014 were studied. Patient demographics, time on dialysis, transplant biopsy findings, biopsy showing recurrence of LN, time to recurrence of LN, acute rejection, renal allograft survival and patient survival were recorded. Chi-square and Student's t-test were used for statistical analysis.

Results: There were 42 Kidney transplant recipients (KTRs): 28 (67%) African American, and10 (24%) Hispanics, 36 (86%) females, with a mean age of 35. Thirty-two (76%) received dialysis prior to transplant: 38 (90%) received live donor kidney transplants. LN recurred in 9 (21%) KTRs: 9 of 36 (25%) females vs 0 of 6 (0%) males, 9 of 38 live donor KTRs vs 0 of 4 deceased donor KTRs, 6 of 32 (19%) with pre-transplant dialysis vs 3 of 10 (30%) with no prior dialysis. The time to recurrent LN was shown in Figure 1. KTRs with recurrent LN were on dialysis for 295+/- 243 days compared to 1206+/-950 days in KTRs without recurrent LN (p=0.0441). There was no difference in graft survival between KTRs with and without recurrent LN. Figure 2.

Conclusions: LN recurred in 25% KTRs with SLE. Females, live donor KTRs, and shorter dialysis time prior to dialysis are risk factors for recurrent LN. Recurrent LN does not have significant impact on renal allograft survival.

CITATION INFORMATION: Tang I, Koganti A, Setty S, Akkina S. Recurrent Lupus Nephritis in a Multi-Ethnic Kidney Transplant Population. Am J Transplant. 2017;17 (suppl 3).

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