Occult Hepatitis C Virus in Recipients of Kidney Transplantation: Prevalence and Clinical Implications.
1Nephrology, Hospital Universitario La Paz/IdiPaz, Madrid, Spain
2Instituto de Estudios Virales, Madrid, Spain
Meeting: 2017 American Transplant Congress
Abstract number: A194
Keywords: Hepatitis C
Session Information
Session Name: Poster Session A: Kidney Complications I
Session Type: Poster Session
Date: Saturday, April 29, 2017
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Hall D1
Occult HCV infection (OCI) is characterized by the presence of HCV- RNA in liver or in peripheral blood mononuclear cells in the absence of serological markers. Infection with HCV is and independent risk factor for graft outcome. However, the prevalence and relationship between kidney outcome and OCI are unknown. The aim of the study is to know the prevalence of OCI in recipients of kidney transplantation and investigate possible clinical implications of OCI in a population of kidney transplantation recipients
Patients and Methods: We randomized tested 133 serum HCV- RNA negative adult pt for the presence of OCI. HCV- RNA was tested by real-time RT- PCR in peripheral blood mononuclear cells and in 2 ml of plasma after ultracentrifugation.
Results: Occult HCV infection was positive in 20 pt (15%). One year after ingraft, renal function and proteinuria were similar for both groups (Cr: 1.58 ± 0,48 mg/dL, 0.40 ± 0.62 gr/d, vs 1,48 ± 0,88 mg/dL, 0.30 ± 0.30 gr/d in the OCI negative). At the end of the follow-up, renal function tended to decline faster in the OCI positive group (Cr: 1.95 ± 1.08) and more proteinuria (0.86 ± 1.14) than in the OCI negative group (Cr:1.78 ± 0.83, and proteinuria 0.63 ±1.41), although without statistical significant (p= 0.072, p=0.429). Table with distributions of demographics and the outcome of renal transplantation between groups of OCI positive and negative.
Conclusions: The prevalence of OCI in recipients of kidney transplantation in our group is 15%, higher than in the general population. The presence of OCI could play a negative role in the outcome of kidney transplants, but more patients and longer follow up, are probably need, to make definitive conclusions.
| Occult positive
(n=20) |
Occult negative
(n=113) |
p | |
| Sex (male) (n,%) | 12 (60) | 73 (64) | 0.43 |
| Age (years) | 54.8 ± 14.28 | 52.65 ± 14.34 | 0.77 |
| Time from Ingraft (months) | 117,7±72,1 | 125,1±79,9 | 0.55 |
| Acute rejection (n,%) | 2 (10) | 13 (14) | 0.21 |
| DGF (n,%) | 2 (10) | 14 (13) | 0.52 |
| Cancer (n,%) | 7 (35) | 18 (17) | 0.05 |
| NODAT (n,%) | 10 (50) | 33 (31) | 0.09 |
| Chronic rejection (n,%) | 2 (10) | 5 (4) | 0.28 |
| Back dialysis (n, %) | 2 (10) | 3 (3) | 0.16 |
| Exitus (n,%) | 2 (10) | 3 (2) | 0.16 |
CITATION INFORMATION: Jimenez C, Olea T, Lopez M, Castillo I, Bartolomé J, Quiroga J, Gonzalez E, Carreño V, Selgas R. Occult Hepatitis C Virus in Recipients of Kidney Transplantation: Prevalence and Clinical Implications. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Jimenez C, Olea T, Lopez M, Castillo I, Bartolomé J, Quiroga J, Gonzalez E, Carreño V, Selgas R. Occult Hepatitis C Virus in Recipients of Kidney Transplantation: Prevalence and Clinical Implications. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/occult-hepatitis-c-virus-in-recipients-of-kidney-transplantation-prevalence-and-clinical-implications/. Accessed November 22, 2024.« Back to 2017 American Transplant Congress