Elderly recipients are listed for renal transplantation (RTx) more frequently. The immediate (first 60 days) post-transplant complications expected in this group have not been well studied. All first RTx with zero PRA, under tacrolimus/MPA/steroids, performed in elderly recipients (≥60y) at our center between 01/10-12/14 were analyzed (n=147) and an equal group of matched younger-controls (by gender, race, donor and induction therapy) was selected. As per design, all demographics were similar (male:63%, whites: 76%) in these two groups differed only by age (66±4 vs 44±11y, p=0.000). All RTx features, deceased donor(84%), mean donor age(44y), last donor eGFR, time on dialysis were also similar.70 pts in each group received basiliximab and 70 ATG. Before RTx EldG presented more co-morbidities. Hospitalization for the RTx procedure was longer for the EldG (18± 18 vs 15±11 days, p=0.004). Acute rejection episodes occurred in 5% of both groups. The number of graft losses (not due to death) was also similar (n=2 for each) and due to vascular complications. Death occurred more frequently in the EldG (16 vs 3, p=0.004) and was mostly due to infection. Dialysis in the first week also occurred more frequently in Eld patients (77 vs 60, p=0.061). Eld G. When we compared complications after renal transplant, EldG presented more cardiovascular complications (3 vs 17, p=0.001) with prevalence of coronary events, hematological (40 vs 26, p = 0.05) mainly anemia when compared to younger patients as well as more ICU admissions (49 vs 20, p=0.000). Surgical, urological, infections, metabolic, neurologic and gastrointestinal complications did no differ between groups. These data confirm that non-sensitized, elderly recipients are a very high risk group for DGF, death due to infection and cardiovascular, and hematological complications after RTx when compared to a younger group. Therefore, the care and immunosuppression regimen for this group should be designed to confront and diminish these complications.

CITATION INFORMATION: Agena F, Paula F, Reichert B, Neves P, Piovesan A, Nahas W, David-Neto E. Which Post-Transplant Complications Are More Common in Elderly Renal Recipients? Am J Transplant. 2016;16 (suppl 3).

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