Introduction:

Living kidney donor transplantation has demonstrated significant survival benefits to individuals with End Stage Renal Disease (ESRD). However, The long term cardiovascular risks associated with kidney donation are unclear.

Methods:

Retrospective data was collected on Kidney donors (n=128) who underwent pre-Kidney donation assessment followed by Donor nephrectomy at our centre ( January 2009 to August 2014). Both QDiabetes^® diabetes and QRISK^®2-2015 Web Calculator were used to calculate 10 year risk of developing Type 2 diabetes and cardiovascular event prior to donation.

Results:

Among the cohort of 128 patients (m= 66, f=62), mean age of donors was 45 ± 10 years. Majority of the donors (62%) were from 5^th to 6^th decade {n=40 (20-39 yrs), n= 43(40-49 yrs), n=37(50-59 yrs), n=16(60-79 yrs.)}. 42 % of the patients were overweight (BMI 25-30 Kg/m2) and 17 % were obese (BMI >30Kg/m2).

Mean Body Mass Index and cholesterol/HDL ratio were 27.34 ± 3.52, 4.08±1.49 in males and 25.80±3.6, 3.43±0.97 in females respectively. The mean Qrisk in men was 6.95% and 5.5% in women. 12.5% of donors had a Qrisk score of > 10% which is considered to be a trigger for intervention. These donors had a trend towards higher number of cardiovascular co-morbidities during follow up (hypertension, hypercholesterolemia) (p = 0.06). The QRISK figures were however lower than in the general population, which averages 8.66% in men and 6.57% in women. The mean Q risk scores for diabetes were 5.05% for men and 3.55% for women. This was again lower than the averages for the general population which are 6.12% (6.05-6.19) for men and 4.72% (4.66-4.78) for women.

Discussion:

This study has demonstrated that QRISK for cardiovascular disease in living kidney transplant donors is generally lower than in the normal population. Donors with a QRISK of > 10% had more cardiovascular comorbidities recorded in follow up although no cardiovascular events were reported during this time frame. The QRISK for Diabetes was also lower than the general population. In conclusion calculation of the QRISK scores for diabetes and cardiovascular comorbidities may be useful in predicting the long term complications following living kidney donation. Donors with QRISK >10% should be considered for prophylactic interventions to reduce post donation cardiovascular risk.

CITATION INFORMATION: Bhutani S, Chinnadurai R, Bernal-Blanco G, Patel B, Summers A, Van Dellen D, Morton M, Michael P. Can Qrisk Be Useful to Predict Future Cardiovascular Co-Morbidites and Type II Diabetes in Living Kidney Donors Prior to Donation? Am J Transplant. 2016;16 (suppl 3).

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