The UK Kidney Donor Risk Index Score Predicts the Development of TRAS Post Deceased Donor Transplantation.
Imperial College Renal and Transplant Centre, Hammersmith Hospital, London, United Kingdom.
Meeting: 2016 American Transplant Congress
Abstract number: B194
Keywords: Donors, Kidney transplantation, marginal, Renal artery stenosis, Renal dysfunction
Session Information
Session Name: Poster Session B: Kidney Transplantation: KDPI, HCV/Matching, Donor Age
Session Type: Poster Session
Date: Sunday, June 12, 2016
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Halls C&D
Introduction: Transplant renal artery stenosis (TRAS) is a heterogeneous disorder with different subtypes and aetiologies, which include traditional cardiovascular and transplant specific risk factors. Whether the increasing use of extended criteria donors, who have a higher incidence of intrinsic cardiovascular risk factors will impact on the incidence of TRAS is not known. The aim of this study is to determine if a high UK kidney donor risk-index (UKKDRI) score is associated with TRAS.
Methods: We performed a retrospective analysis of all transplants performed at our centre between 2005 and 2015. 209/1479 (14.1%) of all patients had TRAS proven by formal angiography.
Results: TRAS prevalence was significantly higher in deceased donors (DD) compared with LD, 152/209 (72.7%) of TRAS developed in DDTx recipients, p<0.0001. The mean time to TRAS diagnosis was 3.5±3.6 months. Demographics were available on 150 deceased donors with TRAS and these were compared with 605 TRAS negative deceased donors.
| Donor Characteristic
|
TRAS+ [N=150 (%)] |
TRAS- [N=605(%)] |
p value | |
| Gender |
Male |
94(62.7) | 291(48.1) | 0.023 |
| Age | Mean (yrs) | 56.91±12.97 | 49.50±15.72 | <0.0001 |
| Ethnicity | Caucasian | 139 (92.7) | 542 (89.6) | 0.33 |
| Graft status (DBD/DCD) | DBD | 117 (78.0) | 492 (81.3) | 0.42 |
| SCD/ECD status | SCD | 54 (36.0) | 336 (55.5) | <0.0001 |
|
Donor hypertension |
Yes | 65 (43.3) | 168 (27.8) | 0.0003 |
| UKKDRI score | High | 81 (53.3) | 213 (35.2) | <0.0001 |
Discussion: A high risk UKKDRI score may enable identification of patients at risk of developing TRAS and knowing donor characteristics may allow a focused screening strategy for TRAS post deceased donor transplantation.
CITATION INFORMATION: Willicombe M, Baheerathan A, Moser S, McLean A, Hammady M, Gedroyc W, Taube D. The UK Kidney Donor Risk Index Score Predicts the Development of TRAS Post Deceased Donor Transplantation. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:
Willicombe M, Baheerathan A, Moser S, McLean A, Hammady M, Gedroyc W, Taube D. The UK Kidney Donor Risk Index Score Predicts the Development of TRAS Post Deceased Donor Transplantation. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/the-uk-kidney-donor-risk-index-score-predicts-the-development-of-tras-post-deceased-donor-transplantation/. Accessed November 22, 2024.« Back to 2016 American Transplant Congress