Background: The aim of this study is to investigate the clinical significance of pre-transplant serum 25-hydroxyvitamin D (25(OH)D) levels in regard to post-transplant clinical outcome in both non-immunologic and immunologic aspects in kidney transplant recipients (KTRs).

Methods: We included 174KTRs with low immunologic risk at baseline. We divided patients into three tertile groups according to baseline serum 25(OH)D level. We compared the post-transplant clinical outcomes such as development of acute rejection, infectious complications and also osteoporosis in post-transplant state.

Result: During the first year after the KT, a total 27 cases of biopsy-proven acute rejection (BPAR) was detected. In the higher tertile, the rate of acute rejection (6.9 %) was significantly lower than that of the lower tertile group (23.7 %) (p=0.012) and high 25(OH)D level was independently associated with low incidence of BPAR in multi-variate analysis. In contrast, serum 25(OH)D levels did not show significant association with either the overall or specific types of infectious complications. In metabolic aspects, lipid profile intact PTH and hemoglobin did not show significant differences among three tertile groups. The incidence of osteoporosis and bone mineral density (BMD) score did not differ across three groups as well.

Conclusions: Pre-transplant serum25(OH)D level isa significant predictor for acute rejection, but it did not show significant association with infection and metabolic complications.

CITATION INFORMATION: Ban T, Kim J, Lee Y, Choi B, Park C, Yang C, Kim Y.-S, Chung B. Clinical Impact of Pre-Transplant Serum 25-Hydroxyvitamin D Levels on the Post-Transplant Immunologic and Non-Immunologic Outcomes in Kidney Transplant Recipients. Am J Transplant. 2016;16 (suppl 3).

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