Background: The trajectory of post-donation eGFR in living donors is poorly described. Our objective was to explore the association between baseline donor characteristics and post-donation eGFR.

Methods: Our study population consisted of 1148 living kidney donors from the Indiana Health Information Exchange of which 89 (7%) were African-American. We retrospectively reviewed most recent renal function follow-up data of living kidney donors derived from electronic health records with a donation date between 1998 and 2014. Estimated glomerular filtration rate (eGFR) was calculated using the CKD-EPI equation. Predictors of follow-up eGFR (CKD-EPI) including age, race and gender were assessed by linear regression with inclusion of two-way interaction to tests for effect modification.

Results: Median (IQR) follow-up time was 1.0 (0.8 to 2.1) years (max =16.9 years). The median age at baseline was 40.4 years. Median (IQR) post-donation eGFR was 62.3 (53.9-72.4) mL/min/1.73m². The multiple regression model accounted for 19% of the variance in eGFR. In the adjusted model, eGFR was higher in African-American donors (p=0.03) and lower in male donors (p 0.003); this association was amplified in younger donors and attenuated in older donors (interaction <0.001). Table 1 shows the characteristics associated with post-donation eGFR (p<0.001).

Conclusion: Post-donation eGFR was lower in male donors than female donors, particularly among younger donors.

CITATION INFORMATION: Henderson M, McFarlane T, Massie A, Segev D, Dixon B. Gender Differences in Longitudinal eGFR of Living Kidney Donors in a Health Information Exchange. Am J Transplant. 2016;16 (suppl 3).

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