Background: Previous studies and current guidelines have suggested that elderly persons can be living kidney donors; however, reports on elderly donors >70 years old are limited. In order to clarify the donor safety and feasibility, we investigate the clinical outcomes of living kidney donors > 70 years old after nephrectomy.

Methods: We conducted a case-series study of living kidney donations involving 48 donors aged >70 years at the time of transplantation. The kidney donations occurred between 2001 and 2014 at our institution. The primary outcomes were survival or end-stage renal disease (ESRD)-free rate and all crude event-free rates, including cardiovascular-, infection-, ESRD-, or death-free rate. The secondary outcome was serum creatinine level at the end of the follow-up period.

Result: The 48 cases were followed up for a median of 4 years. The survival rate among the donors was 100% until the fifth year, and only two donors died during follow-up. The ESRD-free rate was 100% during the follow-up period. The overall event-free rate was 100% at 1 year, 85.7% at 3 years, and 75.0% at 5 years. The mean serum creatinine level was 1.18 ± 0.24 mg/dL at the time of hospital discharge and did not increase (1.18 mg/dL) at the end of follow-up.

Conclusion: Living kidney donation from elderly donors >70 years old appears to be a safe and acceptable option for patients requiring renal-replacement therapy.

CITATION INFORMATION: Hasegawa J, Unagami K, Okumi M, Omoto K, Inui M, Ishida H, Tanabe K. Clinical Outcome of Elderly Living Kidney Donors: A Single-Center Study in Japan. Am J Transplant. 2016;16 (suppl 3).

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