The Prevailing Preference for Left Nephrectomy in Living Donor Transplantation Does Not Adversely Affect Long Term Donor Outcome.
1Department of Transplantation, St. James&apos
University Hospital, Leeds, United Kingdom
2Department of Statistics, University of Leeds, Leeds, United Kingdom.
Meeting: 2016 American Transplant Congress
Abstract number: A117
Keywords: Donors, Kidney, Kidney transplantation, Outcome, unrelated
Session Information
Session Name: Poster Session A: Kidney Donor Outcomes
Session Type: Poster Session
Date: Saturday, June 11, 2016
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Halls C&D
Background: There is a world-wide prevailing clinical bias for removing the left kidney for living donor renal transplant. Both the retrieval and implantation of the left kidney is considered less challenging in this context. We present the largest national study to date comparing donor and recipient outcomes following left or right living donor nephrectomy (LDN).
Methods: A total of 7919 patients undergoing living donor nephrectomy (LDN) and their transplant recipients between Jan 2003 and Dec 2012 were included in the study from 24 centres across UK. Donor outcomes for analysis: hospital stay, intra/post-operative complications, new use of anti-hypertensive drugs, 1-year serum creatinine, eGFR, and creatinine clearance. Recipient outcomes for analysis: Immediate graft function, delayed graft function, premature graft failure, 1-year serum creatinine, eGFR and graft survival.
Results: Of the 7919 donors, 6407(80.1%) were left-LDN and 1512(19.9%) right-LDN. No significant difference was observed in all donor outcomes between left and right LDN, except in incidence of post-operative wound infection (1.3% vs 2.6%, p<0.000). In transplant recipients there was statistical difference in immediate graft function (93.9% vs. 90.8%, p<0.000), delayed graft function (5.0% vs. 6.7%, p<0.009), premature graft failure (1.1% vs 2.5%, p<0.000) and mean graft survival (1443 vs 1658, p<0.000). There was no statistical difference in 1 year serum creatinine or eGFR in recipients receiving kidneys from left or right LDN.
Conclusion: We present the largest study to date comparing donor and transplant outcomes following left or right LDN. There is increased risk of wound infection after right LDN but no significant differences in the long-term outcome of the donor. The recipient of right LDN have increased risk of delayed graft function, premature graft failure and reduced mean graft survival.
CITATION INFORMATION: Robertson S, Garrard L, Farid S, Baker R, Ahmad N, Attia M, Feltbower R, Jameel M, Lutz H. The Prevailing Preference for Left Nephrectomy in Living Donor Transplantation Does Not Adversely Affect Long Term Donor Outcome. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:
Robertson S, Garrard L, Farid S, Baker R, Ahmad N, Attia M, Feltbower R, Jameel M, Lutz H. The Prevailing Preference for Left Nephrectomy in Living Donor Transplantation Does Not Adversely Affect Long Term Donor Outcome. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/the-prevailing-preference-for-left-nephrectomy-in-living-donor-transplantation-does-not-adversely-affect-long-term-donor-outcome/. Accessed November 22, 2024.« Back to 2016 American Transplant Congress