Effect on Endothelial function when Hyperglycemia Is Reversed by Single Pancreas Transplantation.
1Department of Transplant Medicine, Section of Nephrology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
2Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
3Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Oslo, Norway
4Metabolic and Renal Research Group, UiT, The Arctic University of Norway, Tromsø, Norway.
Meeting: 2016 American Transplant Congress
Abstract number: A60
Keywords: Endothelial activation, Hyperglycemia, Pancreas transplantation
Session Information
Session Name: Poster Session A: Clinical Pancreas Transplantation and All Islet Cell Transplantation Topics
Session Type: Poster Session
Date: Saturday, June 11, 2016
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Halls C&D
Background: Endothelial dysfunction is a predictor for future cardiovascular disease. We have previously published that endothelial function improves in renal transplant recipients with post-transplantation diabetes after treatment With rosiglitazone. Whether this change was caused by a pleiotropic effect of the drug or by the improvement in blood sugar excursions is unknown. We aimed to assess if endothelial function improves when hyperglycemia is reversed by single pancreas transplantation in patients with type 1 diabetes.
Methods: Patients were investigated 8 weeks and 1 year after transplantation if they had a functioning pancreas graft. The study procedures included a physical examination, assessment of endothelial function, arterial stiffness and heart rate variability (HRV). Endothelial function was assessed by Flow-mediated dilation (FMD) in arteria brachialis and in the micro vessels of the finger tip by ultrasound and Endo-PAT, respectively, following reactive hyperperfusion induced by occlusion of the artery (ClinicalTrials.gov: NCT02066350).
Results: Median (range) age of the included patients was 39 (21-57) years (14 male, 21 female). Median duration of type 1 diabetes was 23 (3-43) years. Median time on the waiting list was 6.1 (0.8-24.3) months. Preliminary results for 8 patients with 1 year data are shown in the table below.
| Given in median (interquartile range) | 8 weeks post-transplant |
1 year post-transplant |
P-value |
| BMI (kg/m2) | 25.8 (2.4) | 26.2 (3.6) | 0.27 |
| Systolic blood pressure (mmHg) | 119 (18) | 128 (25) | 0.16 |
| Diastolic blood pressure (mmHg) | 79 (17) | 77 (16) | 0.83 |
| Measured glomerular filtration rate (mL/min/1.73m2) | 76 (15) | 76 (28) | 0.18 |
| HbA1c (%) | 6.0 (1.0) | 5.6 (0.4) | 0.04 |
| HRV Valsalva test (bpm) | 1.32 (0.33) | 1.40 (0.99) | 0.04 |
| Maximal increase FMD arteria brachialis (mm) | 0.20 (0.10) | 0.30 (0.30) | 0.07 |
Conclusion: Preliminary results show a significantly improved HRV under the Valsalva test and a numeric improvement in FMD in arteria brachialis 1 year after single pancreas transplantation. Further analyses are under way.
CITATION INFORMATION: Halden T, Eide I, Dahle D, Åsberg A, Reisæter A, Jenssen T, Hartmann A. Effect on Endothelial function when Hyperglycemia Is Reversed by Single Pancreas Transplantation. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:
Halden T, Eide I, Dahle D, Åsberg A, Reisæter A, Jenssen T, Hartmann A. Effect on Endothelial function when Hyperglycemia Is Reversed by Single Pancreas Transplantation. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/effect-on-endothelial-function-when-hyperglycemia-is-reversed-by-single-pancreas-transplantation/. Accessed December 26, 2024.« Back to 2016 American Transplant Congress