2022 American Transplant Congress
Human PBMC-Transferred Murine MHC Class I/II-Deficient NOG Mice Enable Long-Term Evaluation of Human Immune Responses to Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Sheets
Center for Immune Therapeutics and Diagnosis, Juntendo University, Tokyo, Japan
*Purpose: Transplantation of cardiomyocytes sheets derived from allogenic human induced pluripotent stem cells (hiPS-CMs) hold great promise in generating new functional myocardium in situ. However,…2022 American Transplant Congress
Novel Role of CD74 in Regulatory T Cell Homeostasis and Function in Allo-Immune Response
1Brigham and Women's Hospital, Boston, MA, 2Yale University School of Medicine, New Haven, CT
*Purpose: Identifying new molecular targets based on our understanding of the biology of the allo-immune response in the allograft microenvironment is critical to develop more…2022 American Transplant Congress
Gene Profiling to Distinguish Mechanisms of Liver Allograft Rejection and Acceptance in Cynomolgus Monkey
*Purpose: Liver is an immune regulatory organ. Spontaneous resolutions from rejection have been seen in our orthotopic cynomolgus monkey liver transplant models for tolerance induction…2021 American Transplant Congress
Utility of Follow-up Biopsies After Acute Rejection in Pediatric Kidney Transplantation
*Purpose: Treatment of acute kidney transplant rejection in children is often guided by creatinine-based estimates of GFR (eGFR) that may lack sensitivity to determine the…2021 American Transplant Congress
Anti-CD8 Immuno-PET for Non-invasive Tracking of Early Graft Rejection in a Non-human Primate Kidney Transplant Model
*Purpose: Infiltration of CD8 T cells into solid organ grafts is an early sign of rejection. REGN5054 is a fully human monoclonal antibody that binds…2021 American Transplant Congress
Quilty Lesions are Associated with a Tolerance Profile in Heart Allografts Biopsies
Pathology, UTSW Medical Ctr, Dallas, TX
*Purpose: Previously, in 42 cardiac allograft biopsies, we demonstrated that the presence of Foxp3+ innate and TGF- β + adaptive regulatory lymphocytes in Quilty lesions…2021 American Transplant Congress
The Effect of the Different Donor-Derived HLA T-Cell Epitope Targets on the Development of T Cell-Mediated Rejection After Kidney Transplantation
Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
*Purpose: Many kidney allografts fail due to rejections caused by the donor and recipient HLA incompatibility. Recent studies have shown that HLA-DR and DQ mismatches…2021 American Transplant Congress
P40 Homodimers Induce Il-15 to Promote Endogenous Donor-reactive Memory Cd8 T Cell Activation within High-risk Cardiac Allografts
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Longer cold ischemic storage (CIS) time prior to transplant results in increased proliferation of endogenous donor-reactive memory CD8 T cells within complete MHC-mismatched cardiac…2021 American Transplant Congress
Dynamic Reconstitution of Recipient Resident Memory T Cell Repertoire After Human Intestinal Transplantation
Columbia University, New York, NY
*Purpose: Our studies in intestinal transplant (ITx) recipients demonstrated that donor T cell blood macrochimerism(peak level ≥4%) is associated with slower graft T cell replacement…2020 American Transplant Congress
CD11b is a Novel Alternate Receptor for CD154 During Alloimmunity
*Purpose: For decades, blockade of CD40-CD154 has been shown to be a highly effective means of inhibiting alloreactive T cell responses and inducing long-term graft…
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