2022 American Transplant Congress
Evaluation of the Significance of Isolated C4d Staining without Histological Evidence of Rejection on Kidney Biopsies After ABO-Compatible Transplantation in Pediatric Recipients
*Purpose: C4d staining in peritubular capillaries has been part of ABMR Banff definition since 2003. Despite relatively high specificity, c4d staining shows limited sensitivity, and…2022 American Transplant Congress
Transbronchial Cryobiopsy vs Conventional Forceps Biopsy in Lung Transplant Recipients Multicenter Study
*Purpose: Transbronchial biopsy is considered the gold standard in the diagnosis of acute cellular rejection after lung transplantation. There still remains the discussion in conventional…2022 American Transplant Congress
Histopathology at Diagnosis and One-Year Outcomes in Antibody Mediated Rejection in Pediatric Kidney Transplant Recipients: Preliminary Findings from the Paramour “Pediatric Renal AMR Outcomes” Study
*Purpose: Antibody mediated rejection (AMR) is a major cause of kidney allograft dysfunction leading to graft loss. There is a paucity of data regarding how…2022 American Transplant Congress
Diagnostic Performance of Donor-Derived Cell-Free DNA Assay (AlloSure®) in Kidney Transplant Recipients with Graft Dysfunction: A Single Center Study
*Purpose: Circulating donor-derived cell-free DNA (dd-cf-DNA) is a non-invasive biomarker of kidney allograft injury with a high negative predictive value for ruling out active rejection…2022 American Transplant Congress
Deceased Donor Procurement Biopsy Practices, Interpretation, and Histology-Based Decision Making: A Survey of US Transplant Centers
*Purpose: In light of contemporary controversies on the utility of kidney procurement biopsies in predicting allograft outcomes and guiding organ acceptance, we surveyed transplant providers…2022 American Transplant Congress
Surveillance with Protocol Biopsies for Rejection Significantly Impacts Survival Following Intestine Transplant
*Purpose: Frequent surveillance biopsy is required on the first month post intestinal transplant(IT) due to high-risk of acute rejection. However, the utility and the frequency…2022 American Transplant Congress
Using a Unique Repository of Pancreas Transplant Biopsies to Validate the Tissue Common Response Module (tCRM) Score as a Tool to Assess the Severity of Pancreas Transplant Rejection
*Purpose: Analysis of transcriptional data from kidney, heart, liver, and lung transplant rejection led to development of the tissue Common Response Module (tCRM) score based…2022 American Transplant Congress
The Prediction of Renal Allograft Rejection by Time-Dependent Two-Signature Predictors
*Purpose: The study aims to develop RNA signature predictors using preemptive biopsy transcriptome data to predict future allograft rejection and reveal the predictors' time-dependent features.*Methods:…2022 American Transplant Congress
Rapid Formalin-Fixed Deceased Donor Kidney Biopsy Protocol – A Proof Of Concept
*Purpose: Reducing kidney discard is a major priority for the transplant community. While frozen section biopsies are the current standard, they are fraught with technical…2022 American Transplant Congress
Temporal Changes in the Peripheral Immune Profile of Acute Rejection Highlight New Mechanisms of Alloimmunity and Potential Non-Invasive Biomarkers of Rejection in Pediatric Liver Transplantation
*Purpose: Acute rejection (AR) is common in pediatric liver transplantation (LT) and can impact late graft loss. Immune subpopulations mediating AR in LT have not…
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