2017 American Transplant Congress » Poster Session B: Acute and Chronic Rejection

6:00pm-7:00pm

A Novel Microsurgical Penis Transplant Model to Study Distinct Immunologic Features of Urogenital Tissues.

G. Furtmüller, S. Fidder, B. Simons, B. Oh, B. Kern, D. Lough, M. Chicco, C. Brayton, W. Lee, D. Cooney, R. Redett, G. Brandacher.

6:00pm-7:00pm

Allograft Cytokine Activation and Elevated Tissue Indoleamine 2,3-Dioxygenase Gene and Protein Expression in Rejecting Pig Transplants.

T. Merchen,¹ Y. Wang,² R. Lassiter,¹ D. Kleven,³ R. Jajosky,³ M. Winn,² C.-S. Ho,⁵ N. Nahman.⁴

6:00pm-7:00pm

Apoptotic Exosome-Like Vesicles Released During Tissue Injury Trigger IL23/IL-17 Autoimmune Axis and Accelerate Rejection.

M. Dieudé,^1,4 J. Turgeon,^1,4 A. Karakeussian-Rimbault,^1,4 L. Pomerleau,¹ A. Robitaille,¹ N. Grandvaux,¹ É. Boilard,^2,4 M.-J. Hébert.^1,3,4

6:00pm-7:00pm

BKV Clearance Time Correlates with T-Cell Receptor Repertoire Shape and Exhaustion State of BKV-Specific T-Cells in Renal Transplant Patients with Severe BKV Infection.

U. Stervbo,^1,2 M. Nienen,¹ B. Weist,² P. Wehler,² T. Westhoff,¹ H.-D. Volk,² P. Reinke,² N. Babel.^1,2

6:00pm-7:00pm

CMV-Specific CD4⁺ T Cells in CMV-IgG-Seronegative Individuals Protect from CMV Viremia Following Transplantation with a CMV-Seropositive Donor Kidney.

N. Litjens, L. Huang, B. Dedeoglu, R. Meijers, M. Betjes.

6:00pm-7:00pm

Deleting LAG-3 Accelerates Cardiac Allograft Rejection and Augments T Cell Memory in Mice.

J. Erfe,^1,2 C. Yang,¹ D. Ndishabandi,¹ I. Rosales,¹ R. White,¹ P. Russell,¹ R. Colvin,¹ J. Madsen,¹ A. Alessandrini.¹

6:00pm-7:00pm

Differences in Kinetics of IFN-y Production Between Endogenous and Allotransplant-Induced Memory T Cells.

B. Gonzalez-Nolasco, J. Marino, W. Orent, G. Benichou.

6:00pm-7:00pm

Donor Genetic Background Determines the Severity of Delayed Graft Function Following Kidney Transplantation in Mice.

L. Qiu, J.-J. Wang, X. Yeap, Z. Zheng, M. He, M. Abecassis, Z. Zhang.

6:00pm-7:00pm

Donor Macrophage Depletion from CMV-Latently Infected Hearts Abrogates CMV-Accelerated Chronic Rejection.

J. Burg,¹ T. Andoh,² N. Haese,² I. Jones,² S. Orloff,¹ D. Streblow.²

6:00pm-7:00pm

Evaluating T Cell Repopulation Post Alemtuzumab Induction with a Belatacept-Based Regimen.

V. Bendersky, H. Xu, A. Kirk.

6:00pm-7:00pm

Evaluation of Function and TCR signaling Profile of CD57⁺ T Cells in Allo-Specific Immunity.

H. Xu,¹ T. Brennan,¹ Q. Li,² A. Kirk.¹

6:00pm-7:00pm

Generation of Autologous CMV and EBV-Specific T-Cell Lines from Seronegative Patients for Cell Therapy of Opportunistic Infections Following Kidney Transplantation.

C. Lamarche,¹ T. Pincez,¹ J. Orio,¹ C. Carli,¹ A. Humar,² J.-S. Delisle.¹

6:00pm-7:00pm

IL-3 Contributes to Development of Basophil-Triggered Cardiac Allograft Fibrosis Development.

G. Schiechl-Brachner,¹ M. Rodriguez Gomez,¹ K. Renner,¹ S. Buchtler,¹ K. Schmidbauer,¹ D. Halbritter,¹ S. Neumayer,¹ Y. Talke,¹ H. Bruehl,² M. Mack.¹

6:00pm-7:00pm

Immune Activation and Rejection Risk in HIV-Positive Kidney Transplantation.

S. Wisel, B. Shaw, L. Lee, K. Lee, C. Leung, P. Stock, Q. Tang.

6:00pm-7:00pm

Immune Monitoring-Guided Treatment of a Pediatric Patient with Sequential GvHD, Acute Rejection and CMV Infection Following Lung Transplantation.

C. Falk,¹ S. Nicolaus,² M. Carsten,² T. Igor,³ S. Wiebke,³ D. Kerstin,¹ K. Jana,² H. Gesine,² H. Axel,³ W. Gregor.³

6:00pm-7:00pm

Inhibition of Bruton Tyrosine Kinase Blocks Sensitization in Response to Allogeneic Skin Transplantation and Prolong Skin Graft Survival.

N. Datta, T. Palumbo, J. Kupiec-Weglinski, A. Zarrinpar.

6:00pm-7:00pm

Inhibition of Heat Shock Protein 90 Suppresses the Expression of MHC Class I Molecules, but Not MHC Class II Molecules, on Endothelial Cells in Allografts.

T. Tanaka, T. Maehana, N. Masumori.

6:00pm-7:00pm

Is Thymic Function Determining Rejection Onset in Heart Transplantation?

A. Sannier,^1,2 R. Dorent,^1,3 M. Le Borgne,¹ N. Stroumza,¹ J. Senemaud,¹ L. Louedec,¹ F. Andreata,¹ A. Gaston,¹ C. Deschildre,¹ P. Nataf,^1,3 A. Couvelard,² G. Caligiuri,¹ A. Nicoletti.¹

6:00pm-7:00pm

Kidney Recipients with 10 Year Belatacept-Treatment Display an Altered T Cell Subset Composition and Low Plasma Cytokine Levels Compared to Matched Patients with CNI-Based Immunosuppression.

C. Falk,¹ C. Neudörfl,¹ A. Scherf,¹ K. Daemen,¹ J. Keil,¹ J. Klempnauer,² F. Lehner,² G. Grannas.²

6:00pm-7:00pm

Lymphoid Isolation as an Adjuvant Maneuver for Belatacept-Based Immunotherapy.

M. Mulvihill,¹ K. Samy,² R. Davis,¹ F. Leopardi,¹ B. Collins,¹ A. Kirk.¹

6:00pm-7:00pm

Mechanisms of Fibrosis in the Allograft Kidney: RNA-seq Based Analysis Using Formalin Fixed Biopsies.

G. Zeng,² L. Pan,¹ Z. Lyu,¹ Y. Huang,² P. Randhawa.²

6:00pm-7:00pm

Mitochondrial Permeability Can Regulate Endothelial Cell Necroptosis and Promote Cardiac Allograft Rejection.

I. Gan,^1,2 J. Jiang,¹ D. Lian,¹ A. Jevnikar,^1,3 Z.-X. Zhang.^1,2

6:00pm-7:00pm

Patients with Renal Failure Have a pERK-Dependent Defective TCR-Mediated Activation of CD4⁺ T Cells.

L. Huang, N. Litjens, N. Kannegieter, M. Klepper, C. Baan, M. Betjes.

6:00pm-7:00pm

RAS Inhibition Attenuates Urine Angiotensin II-Regulated Proteins Associated with Interstitial Fibrosis and Tubular Atrophy in Kidney Transplant Recipients.

Z. Mohammed-Ali,¹ S. Reid,³ P. Yip,¹ H. Cardinal,² M.-J. Hébert,² Y. Li,⁴ S. Kim,^1,3,4 A. Konvalinka.^1,3

6:00pm-7:00pm

Recipient iNOS Deficiency Reduces Spontaneous Kidney Allograft Acceptance by Accelerating Allograft Loss.

I. Aljabban, B. Jiang, C. Yang, D. Ndishabandi, R. White, P. Russell, J. Madsen, R. Colvin, A. Alessandrini.

6:00pm-7:00pm

TGF-β1 Induces Transplant Kidney Interstitial Fibrosis Through Endothelial-to-Mesenchymal Transition via TGF-β/Smad and Akt/mTOR/p70S6K Pathways.

Z. Wang, Z. Han, J. Tao, R. Tan, M. Gu.

6:00pm-7:00pm

Type-1 Interferon Impairs the Immunoregulatory Activity of IL-10: A Mechanism in the Abrogation of Transplant Tolerance.

M. Iglesias, A. Arun, B. Lam, W. Lee, G. Raimondi, G. Brandacher.

6:00pm-7:00pm

Vimentin Regulates ß-Catenin Translocation During Epithelial to Mesenchymal Transition in Renal Fibrosis.

R. Lopez-Soler, Z. Wang, A. Divanyan.