Date: Tuesday, May 2, 2017
Session Name: Poster Session D: Kidney: Acute Cellular Rejection
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
Hahnemann University Hospital has performed 113 kidney transplants, including 7 ReTx. Herein we describe characteristics and allograft outcomes of HIV(+) kidney transplant recipients based on ReTx status.
Methods: We compared recipient, donor, allograft characteristics between ReTx(n=7) and PrimTx(n=106) HIV(+) kidney recipients at a single center. Immunosuppression consisted of antibody induction (basiliximab (n=112), antithymocyte globulin (n=1,ReTx), and concomitant IVIG (n=19, 2 ReTx/17 CRD)), calcineurin-inhibitor, antiproliferatives, and prednisone. Rejections and allograft outcomes were analyzed between the two cohorts.
Results: Patient characteristics were similar, except more female ReTx (Table 1).Rejection rates were increased in the ReTx cohort (figure 1), which likely impacted survival. Kaplan-Meier curve for allograft survival is shown in figure 2.
Conclusion: Both PrimTx and ReTx HIV(+) kidney recipients are at high risk for rejection and allograft failure. Future studies may focus on the ideal immunosuppression required to improve outcomes for HIV(+) ReTx recipients.
|Recipient Age (years)||47±7||48±0||0.81|
|Protease Inhibitor based ART||71%||51%||0.29|
|Donation after Cardiac Death||14%||10%||0.75|
|Delayed Graft Function||57%||57%||0.98|
CITATION INFORMATION: Malat G, Guy S, Ranganna K, Reich D, Xiao G, Talluri S, Harhay M, Levin Mizrahi L, Culkin C. Long-Term Outcomes in HIV(+) Kidney Re-Tranpslant (ReTx) Recipients vs. Primary Transplant (PrimTx) Recipients. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:Malat G, Guy S, Ranganna K, Reich D, Xiao G, Talluri S, Harhay M, Levin L, Culkin C. Long-Term Outcomes in HIV(+) Kidney Re-Tranpslant (ReTx) Recipients vs. Primary Transplant (PrimTx) Recipients. [abstract]. Am J Transplant. 2017; 17 (suppl 3). http://atcmeetingabstracts.com/abstract/long-term-outcomes-in-hiv-kidney-re-tranpslant-retx-recipients-vs-primary-transplant-primtx-recipients/. Accessed December 18, 2017.
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