Background: The KDRI score has emerged as an important tool to assess donor characteristics that are associated with differences in graft survival. How KDRI scores translate into the graft outcomes of HIV+ kidney transplant recipients has not been well-characterized. We sought to define the association of the KDRI score on allograft survival of HIV (+) kidney transplant recipients.
Methods: 91 sequential HIV+ kidney transplant recipients since 2001 were retrospectively examined. For each patient, a KDRI score was calculated and compared with the reference donor as described by Rao et al. Unadjusted KDRI scores were plotted against kidney allograft survival.
Results: The demographics for the group are described in Table 1. A scatter plot was used to visualize an assocation using KDRI vs. long term graft survival (Figure 1) and 3 year estimated glomerular filtration rate (Figure 2). Neither r2 value suggested an association between KDRI and kidney allograft survival.
Conclusions: We did not find a clear relationship between unadjusted KDRI scores and allograft survival among a single center cohort of HIV+ kidney transplant recipients. This was unexpected because of ours and others reported associations between allograft outcomes and delayed graft function. We suggest that HIV+ patients represent a unique population in which standard predictors of graft survival may perform less well.
|Male (%)||78 (86)|
|Age (mean ± s.d)||48.1 ± 9.0|
|African-American (%)||81 (89)|
|Cold ischemia time (mean ± s.d.)||16.2 ± 5.8|
|Delayed Function(%)||56 (62)|
|Acute Cellular Rejection (%)||64 (71)|
|Acute Humoral Rejection (%)||14 (15)|
|1st eGFR (mean ± s.d.)||34.8 ± 28.7|
|3rd eGFR (mean ± s.d.)||22.0 ± 29.8|
|KDRI (mean ± s.d.)||1.38 ± 0.52|
To cite this abstract in AMA style:Malat G, Ranganna K, Guy S, Xiao G, Reich D, Doyle A. KDRI Scores Did Not Correlate with Allograft Survival ForA Cohort of HIV (+) Kidney Transplant Recipients [abstract]. Am J Transplant. 2013; 13 (suppl 5). http://atcmeetingabstracts.com/abstract/kdri-scores-did-not-correlate-with-allograft-survival-fora-cohort-of-hiv-kidney-transplant-recipients/. Accessed February 21, 2018.
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