Date: Sunday, June 12, 2016
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Halls C&D
Introduction: Concordance of allograft outcomes between kidneys transplanted from the same donor has previously been reported. However recipient characteristics become increasingly important after the immediate post-transplant period. The aim of this study was to demonstrate the correlation of outcomes between paired donor kidneys transplanted at a single unit receiving a homogeneous immunotherapy protocol and to define the time when recipient characteristics become more important.
Methods: 226 (113 donor pairs) patients were analysed. Pairs were randomly assigned into 2 groups, ensuring there was an equal distribution of first and second transplanted kidneys in each group. Mean follow up was 4.91±4.6 years.
Results: Correlation of inter-pair allograft outcomes (assessed by attributable risk) are shown in the table 1.
|Event||Odds ratio (95% CI)||p value|
|Patient Loss||2.53 (0.43-14.75)||0.15|
|Allograft Loss||4.96 (1.48-16.61)||0.013|
|Delayed Graft Function||2.85 (1.33-6.12)||0.0063|
|De novo DSA||0.76 (0.25-2.33)||0.66|
Assessment of the correlation in function (assessed by spearman's coefficient) is shown in the table 2.
|eGFR at time point||rho||p value|
There is a significant correlation in DGF, function in the 1st year and overall allograft survival in pairs of kidneys transplanted from the same donor. However, rejection, DSA development and function after the 1st year are more dependent upon recipient characteristics.
Discussion: Knowing the clinical outcomes of the contralateral kidney in the first year post-transplant may help in managing transplant recipients, as discordance might initiate investigation of dysfunction caused by recipient factors.
CITATION INFORMATION: Baheerathan A, Beckwith H, McLean A, Taube D, Willicombe M. Clinical Correlation Between Pairs of Kidneys Transplanted from the Same Donor. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:Baheerathan A, Beckwith H, McLean A, Taube D, Willicombe M. Clinical Correlation Between Pairs of Kidneys Transplanted from the Same Donor. [abstract]. Am J Transplant. 2016; 16 (suppl 3). http://atcmeetingabstracts.com/abstract/clinical-correlation-between-pairs-of-kidneys-transplanted-from-the-same-donor/. Accessed September 26, 2017.
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